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Titolo:
INFLUENCE OF BRAIN HISTAMINE ON GROWTH-HORMONE SECRETION INDUCED BY ALPHA-2-RECEPTOR ACTIVATION
Autore:
NETTI C; SIBILIA V; GUIDOBONO F; PECILE A;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
Neuroendocrinology
fascicolo: 6, volume: 57, anno: 1993,
pagine: 1066 - 1070
SICI:
0028-3835(1993)57:6<1066:IOBHOG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESYNAPTIC H-3 RECEPTORS; RAT-BRAIN; RELEASE; CATECHOLAMINES; MODULATION; INHIBITION; TURNOVER; CORTEX; SYSTEM; STRESS;
Keywords:
HISTAMINE; H3 AGONIST; CLONIDINE; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C. Netti et al., "INFLUENCE OF BRAIN HISTAMINE ON GROWTH-HORMONE SECRETION INDUCED BY ALPHA-2-RECEPTOR ACTIVATION", Neuroendocrinology, 57(6), 1993, pp. 1066-1070

Abstract

The effects of histamine (HA) and of (R) alpha-methyl-histamine (alpha-MeHA; a drug that decreases histaminergic tone through activation ofpresynaptic H-3 receptors) on growth hormone (GH) secretion induced by clonidine (CLO), an alpha2-adrenergic agonist, were examined in rats. HA (0.1 mumol/rat intracerebroventricularly) and alpha-MeHA (10 mg/kg i.a.) were administered 5 min and 3 h, respectively, before CLO (0.25 mg/kg i.a.). Blood samples for hormone determination were drawn fromfreely moving rats at various times before and after drug treatment. To characterize the mechanisms underlying the inhibition of GH secretion by HA, the effect of HA on GH induced by CLO was examined in rats depleted of catecholamine by pretreatment (2 h before) with alpha-methyl-p-tyrosine (alpha-MpT, 200 mg/kg s.c.) and in rats depleted of somatostatin by pretreatment (4 h before) with cysteamine (300 mg/kg s.c.). HA completely suppressed the GH-releasing effect of CLO whereas alpha-MeHA significantly enhanced the GH response to CLO. Neither alpha-MpTnor cysteamine pretreatment modified the inhibitory activity of HA onGH secretion elicited by CLO. The present results indicate that the inhibitory activity of brain HA on GH release consequent to activation of central alpha2-receptors does not involve a modulatory action on catecholaminergic or somatostatinergic neurons but probably other mechanisms like the modulation of neurons synthetizing GH-releasing hormone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 23:23:01