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Titolo:
TETRAETHYLAMMONIUM BLOCKADE OF K+ CHANNELS IN GH4C1 CELLS REGULATES PROLACTIN SECRETION BY INDUCING CA2+ INFLUX
Autore:
WANG X; INUKAI T; GREER MA;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT MED,ENDOCRINOL SECT PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MED,ENDOCRINOL SECT PORTLAND OR 97201
Titolo Testata:
Cell calcium
fascicolo: 8, volume: 14, anno: 1993,
pagine: 573 - 580
SICI:
0143-4160(1993)14:8<573:TBOKCI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; RAT LACTOTROPH CELLS; PITUITARY-CELLS; POTASSIUM CHANNELS; GROWTH-HORMONE; FREE CALCIUM; SOMATOSTATIN; CA-2+; DOPAMINE; CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
X. Wang et al., "TETRAETHYLAMMONIUM BLOCKADE OF K+ CHANNELS IN GH4C1 CELLS REGULATES PROLACTIN SECRETION BY INDUCING CA2+ INFLUX", Cell calcium, 14(8), 1993, pp. 573-580

Abstract

Tetraethylammonium (TEA), a K+ channel blocker, induced PRL secretionand an increase in cytosol Ca2+ concentration [Ca2+]i in a dose-dependent manner between 5-20 mM in GH4C1 rat PitUitary tumor-derived cells. Removal of medium Ca2+ or the addition of 1 muM nifedipine abolishedboth the induced [Ca2+]i increment and PRL secretion. TEA augmented the TRH-induced rise in [Ca2+]i and inhibited the rise in [Ca2+]i induced by 30 mM K+. The dynamics of TEA-, TRH- and K+-induced PRL secretion were different, with the TEA-induced secretory peak occurring at about 10 min compared to 2-3 min for TRH and K+. Tolbutamide, which blocks ATP-sensitive K+ channels, induced PRL secretion without causing a rise in [Ca2+]i. The results suggest that: (a) K+ channels have a complex interaction with the PRL secretory process in GH4C1 cells; (b) TEA induces PRL secretion by causing Ca2+ influx through dihydropyridine-sensitive Ca2+ channels; and (c) K+ channels play a different role in the [Ca2+]i rise induced by TRH than in that induced by depolarizing K+.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:50:53