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Titolo:
MICROCOMPUTER-ASSISTED KINETIC MODELING OF MAMMALIAN GENE-EXPRESSION
Autore:
HARGROVE JL;
Indirizzi:
UNIV GEORGIA,DEPT FOODS & NUTR ATHENS GA 30602
Titolo Testata:
The FASEB journal
fascicolo: 12, volume: 7, anno: 1993,
pagine: 1163 - 1170
SICI:
0892-6638(1993)7:12<1163:MKMOMG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA SPLICING INVITRO; MESSENGER-RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE; EUKARYOTIC CELLS; INITIATION; TRANSCRIPTION; STABILITY; OVALBUMIN; STABILIZATION; PARAMETERS;
Keywords:
GENE EXPRESSION; MESSENGER RNA; PROTEIN SYNTHESIS; MATHEMATICAL MODELING; COMPUTER SOFTWARE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Hargrove, "MICROCOMPUTER-ASSISTED KINETIC MODELING OF MAMMALIAN GENE-EXPRESSION", The FASEB journal, 7(12), 1993, pp. 1163-1170

Abstract

New software for microcomputers enables predictive, quantitative models of genetic systems to be produced that can account for the elementsof time, scale, and feedback control of hierarchical systems. The flow of genetic information during protein synthesis can be addressed by treating each intermediate as a kinetic element in a linked series of reactions. When the rate of transcription changes, the time required to achieve a new level of the encoded protein is expected to be a function of the conversion rates or half-lives of all intermediates. Kinetic modeling may be used to make predictions and integrate primary data concerning rates of transcription, nuclear mRNA dynamics, nucleocytoplasmic transport, translational control, and other processes that govern the rate of synthesis for specific proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:38:01