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Titolo:
TANDEM SH2 DOMAINS OF ZAP-70 BIND TO T-CELL ANTIGEN RECEPTOR-ZETA ANDCD3-EPSILON FROM ACTIVATED JURKAT T-CELLS
Autore:
WANGE RL; MALEK SN; DESIDERIO S; SAMELSON LE;
Indirizzi:
NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892 JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GENET BALTIMORE MD 21205
Titolo Testata:
The Journal of biological chemistry
fascicolo: 26, volume: 268, anno: 1993,
pagine: 19797 - 19801
SICI:
0021-9258(1993)268:26<19797:TSDOZB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; SIGNAL TRANSDUCTION; PDGF RECEPTOR; CHAIN; PHOSPHORYLATION; ASSOCIATION; CD4; LYMPHOCYTES; INDUCTION; P59FYN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Wange et al., "TANDEM SH2 DOMAINS OF ZAP-70 BIND TO T-CELL ANTIGEN RECEPTOR-ZETA ANDCD3-EPSILON FROM ACTIVATED JURKAT T-CELLS", The Journal of biological chemistry, 268(26), 1993, pp. 19797-19801

Abstract

A proximal and critical biochemical event upon T cell antigen receptor (TCR) stimulation is the activation of a protein tyrosine kinase (PTK) pathway. ZAP-70, a PTK of the p72syk family, associates with phosphorylated TCR subunits upon TCR stimulation. Here we report that the tandem SH2 domains of ZAP-70, expressed as a fusion protein, bind to tyrosine-phosphorylated CD3epsilon and TCRzeta from activated Jurkat T cell lysates. The single N- and C-terminal SH2 domains of ZAP-70, expressed separately, do not bind these TCR subunits. In comparison to fusion proteins containing SH2 domains from other proteins, the tandem SH2 domains of ZAP-70 demonstrate a remarkably restricted repertoire of protein binding, binding only TCRzeta and CD3epsilon. ZAP-70 is also recovered in the binding assay, but this is likely to be a consequence ofits interaction with multiple SH2 binding sites on the zeta-zeta and CD3epsilon-containing dimers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:28:34