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Titolo:
CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR (COUP-TF) BINDS TO A PEROXISOME PROLIFERATOR-RESPONSIVE ELEMENT AND ANTAGONIZES PEROXISOME PROLIFERATOR-MEDIATED SIGNALING
Autore:
MIYATA KS; ZHANG BW; MARCUS SL; CAPONE JP; RACHUBINSKI RA;
Indirizzi:
MCMASTER UNIV,DEPT BIOCHEM HAMILTON L8N 3Z5 ONTARIO CANADA MCMASTER UNIV,DEPT BIOCHEM HAMILTON L8N 3Z5 ONTARIO CANADA
Titolo Testata:
The Journal of biological chemistry
fascicolo: 26, volume: 268, anno: 1993,
pagine: 19169 - 19172
SICI:
0021-9258(1993)268:26<19169:COUPTF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE RECEPTOR SUPERFAMILY; ACYL-COA OXIDASE; THYROID-HORMONE; RETINOIC ACID; BETA-OXIDATION; RAT-LIVER; GENE; MEMBER; IDENTIFICATION; DEHYDROGENASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Miyata et al., "CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR (COUP-TF) BINDS TO A PEROXISOME PROLIFERATOR-RESPONSIVE ELEMENT AND ANTAGONIZES PEROXISOME PROLIFERATOR-MEDIATED SIGNALING", The Journal of biological chemistry, 268(26), 1993, pp. 19169-19172

Abstract

Peroxisome proliferators form a family of diverse xenobiotic compounds that includes hypolipidemic agents, herbicides, and plasticizers. These compounds activate transcription of a subset of nuclear genes including those encoding peroxisomal fatty acid beta-oxidation enzymes, whose elevated activities can lead to hepatocarcinogenesis. Induction ofthe genes encoding fatty acyl-CoA oxidase and hydratase-dehydrogenase, the first and second enzymes of the pathway, is mediated by peroxisome proliferator-activated nuclear receptors (PPARs) that bind to upstream responsive elements (PPREs) through heterodimerization with retinoid X receptors. We demonstrate that the chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1), another member of the nuclearhormone receptor superfamily, binds to the hydratase-dehydrogenase PPRE in vitro and in vivo and antagonizes PPAR-dependent signaling. These data suggest that members of the COUP-TF family play a role in modulating receptor-mediated activation of peroxisome proliferator-responsive genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:11:22