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Titolo:
TRANSPORT AND PRODUCTION OF CEREBROSPINAL-FLUID (CSF) CHANGE IN AGINGHUMANS UNDER NORMAL AND DISEASED CONDITIONS
Autore:
KLEINE TO; HACKLER R; LUTCKE A; DAUCH W; ZOFEL P;
Indirizzi:
UNIV MARBURG,ZENTRUM NERVENHEILKUNDE,FUNKT BEREICH NEUROCHEM MED,RUDOLF BULTMANN STR 8 D-35039 MARBURG GERMANY UNIV MARBURG,ZENTRUM NERVENHEILKUNDE,NEURORADIOL MED ABT D-35039 MARBURG GERMANY UNIV MARBURG,NEUROCHIRURG KLIN & POLIKLIN D-35039 MARBURG GERMANY UNIV MARBURG,ANWENDUNG HSCH ZENTRUM D-35039 MARBURG GERMANY
Titolo Testata:
Zeitschrift fur Gerontologie
fascicolo: 4, volume: 26, anno: 1993,
pagine: 251 - 255
SICI:
0044-281X(1993)26:4<251:TAPOC(>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOROID-PLEXUS; PROTEIN; TRANSTHYRETIN; BRAIN;
Keywords:
CEREBROSPINAL FLUID (CSF); CSF PRODUCTION; CSF TRANSPORT; VENTRICULAR PREALBUMIN; SERUM PREALBUMIN; BLOOD-BRAIN-BARRIER; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T.O. Kleine et al., "TRANSPORT AND PRODUCTION OF CEREBROSPINAL-FLUID (CSF) CHANGE IN AGINGHUMANS UNDER NORMAL AND DISEASED CONDITIONS", Zeitschrift fur Gerontologie, 26(4), 1993, pp. 251-255

Abstract

In three control groups of lumbar (L), cisternal (C), and ventricular(V) cerebrospinal fluid (CSF) with prealbumin contents of ventricularorigin (CSF-V-prealbumin) within the reference range, indications foran increased transport of V-CSF into spinal space are presented in the elderly as well as an elevated production of V-CSF. Indications for a diminished V-CSF production, respectively, an increased transport ofCSF-V-prealbumin into the spinal space were found in elderly patientssuffering from diverse CNS diseases. As these alterations proved to be not disease-specific, the age-related increase of CSF transport was discussed with respect to brain atrophy and enlarged CSF spaces in theelderly central nervous system (CNS). CSF serum prealbumin content, an indicator of blood-brain-barrier function, increased with age similarly to albumin in the ''normal' elderly, respectively with diverse CNSdiseases. Age- and disease-related decreases of albumin and prealbumin contents in blood serum may lead to wrong interpretations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:22:02