Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENTIAL DEVELOPMENT OF THE STRESS-RESPONSE IN CONGENITAL LEARNEDHELPLESSNESS
Autore:
KING JA; CAMPBELL D; EDWARDS E;
Indirizzi:
UNIV MARYLAND,DEPT PHARMACOL & TOXICOL BALTIMORE MD 21201 UNIV MARYLAND,DEPT PHARMACOL & TOXICOL BALTIMORE MD 21201 LRS DIAGNOST ATLANTA GA 30322 TEMPLE UNIV,COLL MED,DEPT MED PHILADELPHIA PA 19122
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 4, volume: 11, anno: 1993,
pagine: 435 - 442
SICI:
0736-5748(1993)11:4<435:DDOTSI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; ANTERIOR-PITUITARY GLAND; ANIMAL-MODEL; GLUCOCORTICOID RECEPTOR; RAT-BRAIN; CORTICOTROPIC ACTIVITY; DEPRESSION; SEROTONIN; BINDING; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
J.A. King et al., "DIFFERENTIAL DEVELOPMENT OF THE STRESS-RESPONSE IN CONGENITAL LEARNEDHELPLESSNESS", International journal of developmental neuroscience, 11(4), 1993, pp. 435-442

Abstract

Early in the development of the hypothalamic-pituitary-adrenal (HPA) axis, the rat undergoes a stress hyporesponsive period of blunted responses to several stressors including cold exposure (CE) and maternal deprivation (MD). We examined the development of the axis by monitoringadrenocorticotropin hormone (ACTH) plasma levels in an animal model of depression and/or anxiety characterized by learned helpless (LH) behavior and a dysfunctional HPA axis in adult life. On postnatal day 7 there was no significant difference in basal plasma ACTH levels betweencongenital (cLH) and controls, but cLH animals showed a blunted response to CE (P<0.001). By postnatal day 14 there was a dramatic increasein ACTH response to CE (P<0.005). On postnatal day 21 baseline ACTH and response to CE were again significantly suppressed in cLH rats. Stress responsiveness to MD was present in all groups and was insignificantly different for all ages of development between groups. These findings suggest that rats with congenital learned helplessness undergo a differential response in the development of the HPA axis in that the axis was hypersensitive at postnatal day 14 and became hyporesponsive beyond day 14, and this may, in part, account for the dysfunctional stress response observed during adulthood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:00:29