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Titolo:
EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) BY RAT ALVEOLAR MACROPHAGES DURING CHRONIC LUNG INJURY
Autore:
BRIELAND JK; JONES ML; FLORY CM; MILLER GR; WARREN JS; PHAN SH; FANTONE JC;
Indirizzi:
UNIV MICHIGAN,SCH MED,LAB ANIM MED UNIT,018 ANIM RES FACIL ANN ARBOR MI 48109 UNIV MICHIGAN,SCH MED,DEPT PATHOL ANN ARBOR MI 48109
Titolo Testata:
American journal of respiratory cell and molecular biology
fascicolo: 3, volume: 9, anno: 1993,
pagine: 300 - 305
SICI:
1044-1549(1993)9:3<300:EOMCP(>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; BLOOD MONONUCLEAR LEUKOCYTES; AMINO-ACID ANALYSIS; GROWTH-FACTOR; CELL-LINES; GENE JE; BLEOMYCIN; FIBRONECTIN; SECRETION; FIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Brieland et al., "EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) BY RAT ALVEOLAR MACROPHAGES DURING CHRONIC LUNG INJURY", American journal of respiratory cell and molecular biology, 9(3), 1993, pp. 300-305

Abstract

Using a well-characterized model of bleomycin-induced pulmonary fibrosis in the rat, we determined that there was a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. Northern hybridization analysis revealed markedly increased expressionof rat monocyte chemoattractant protein-1 (MCP-1) mRNA in alveolar macrophages (AMs) from rats following induction of pulmonary fibrosis. Monocyte chemotactic activity was also significantly increased in conditioned media from AMs retrieved from injured rat lungs. These data suggest that one important role of AMs in the pathogenesis of chronic inflammatory lung injury and pulmonary fibrosis is the regulation of monocyte recruitment and activation within the lung secondary to secretionof monocyte chemoattractants including MCP-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:19:45