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Titolo:
IMPAIRED BINDING-PROPERTIES OF ENDOTHELIN-1 RECEPTORS IN HUMAN ENDOMETRIAL CARCINOMA TISSUE
Autore:
BENBARUCH G; SCHIFF E; GALRON R; MENCZER J; SOKOLOVSKY M;
Indirizzi:
DEPT OBSTET & GYNECOL,853 JEFFERSON AVE E102 MEMPHIS TN 38103 CHAIM SHEBA MED CTR,SACKLER SCH MED,DEPT OBSTET & GYNECOL IL-52621 TEL HASHOMER ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Cancer
fascicolo: 6, volume: 72, anno: 1993,
pagine: 1955 - 1958
SICI:
0008-543X(1993)72:6<1955:IBOERI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE; CELLS;
Keywords:
ENDOTHELIN-1; ENDOTHELIN RECEPTORS; ENDOMETRIAL CARCINOMA; BINDING ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
G. Benbaruch et al., "IMPAIRED BINDING-PROPERTIES OF ENDOTHELIN-1 RECEPTORS IN HUMAN ENDOMETRIAL CARCINOMA TISSUE", Cancer, 72(6), 1993, pp. 1955-1958

Abstract

Background. Endothelins, potent stimulators of smooth muscle tissue activity, were recently shown to also function as mitogens for numerouscell types. The authors investigated the properties of endothelin-1 (ET-1) receptors in human endometrial tissue compared with human endometrial carcinoma tissue. Methods. Tissue samples from 13 patients with endometrial carcinoma and from 12 women undergoing hysterectomy due touterus myomatous were obtained immediately after surgical removal. Binding properties of the endothelin receptors were studied using I-125-labeled ET-1. Results. A significant difference was demonstrated between binding properties of ET-1 receptors of these two groups. The mean maximal density (B(max)) value of the normal endometrial samples was 2029 +/- 341 fmol/mg protein, whereas that of the neoplastic samples was 356 +/- 121 fmol/mg protein. No differences were found, however, between the mean dissociation constant (K(d)) values of these groups. Conclusions. These results might be compatible with the increased blood flow that characterizes malignant endometrial tissue. However, they do not indicate an important mitogenic role for ET-1 in the development of endometrial cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:14:33