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Titolo:
MYOSITIS IN LYME BORRELIOSIS - AN IMMUNOHISTOCHEMICAL STUDY OF 7 PATIENTS
Autore:
MULLERFELBER W; REIMERS CD; DEKONING J; FISCHER P; PILZ A; PONGRATZ DE;
Indirizzi:
UNIV MUNICH,FRIEDRICH BAUR INST,DEPT NEUROL & INTERNAL MED,ZIEMSSENSTR 1A D-80336 MUNICH GERMANY LAB PUBL HLTH FRIESLAND,DEPT PATHOL ANAT 8900 JA LEEUWARDEN NETHERLANDS
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 118, anno: 1993,
pagine: 207 - 212
SICI:
0022-510X(1993)118:2<207:MILB-A>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED CYTO-TOXICITY; MONONUCLEAR-CELLS; INFLAMMATORY MYOPATHIES; UNUSUAL MANIFESTATIONS; DISEASE; BURGDORFERI; INTERLEUKIN-1; QUANTITATION; PATHOGENESIS; EXPRESSION;
Keywords:
MYOSITIS; LYME DISEASE; BORRELIA-BURGDORFERI; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
W. Mullerfelber et al., "MYOSITIS IN LYME BORRELIOSIS - AN IMMUNOHISTOCHEMICAL STUDY OF 7 PATIENTS", Journal of the neurological sciences, 118(2), 1993, pp. 207-212

Abstract

Myositis is a rare complication of Lyme disease. In order to get information about the pathogenesis of this disorder, muscle specimens of 7patients suffering from myositis as a manifestation of Lyme borreliosis were examined by immunohistology. Lyme spirochetes could be found in muscle biopsies of 6 patients. Infiltrates consisted mainly of macrophages and T helper/inducer cells. The T4/T8 ratio was 1.7 in the endomysium and 2.1 in the perimysium. Increased expression of MHC-I molecules by several muscle fibers was observed in 2 subjects only. No MHC-II molecules were expressed by muscle fibers. Lymphocytes expressing the interleukin-2 receptor were detected in 2 patients. Leu-15+ and Leu-11+ cells were found only to a slight extent in 2 patients. In conclusion the immunohistochemical findings in myositis due to Lyme borreliosis are different from other manifestations of this disease, and also from other forms of myositis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:06:54