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Titolo:
ENDOTRACHEAL ADMINISTRATION OF TOLAZOLINE IN HYPOXIA-INDUCED PULMONARY-HYPERTENSION
Autore:
CURTIS J; ONEILL JT; PETTETT G;
Indirizzi:
CHILDRENS MERCY HOSP,NEONATAL MED SECT,2401 GILLHAM RD KANSAS CITY MO64108 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,NEONATAL MED SECT BETHESDA MD 20814 WALTER REED ARMY MED CTR,DEPT PEDIAT WASHINGTON DC 20307 WALTER REED ARMY MED CTR,DEPT CLIN INVEST WASHINGTON DC 20307
Titolo Testata:
Pediatrics
fascicolo: 3, volume: 92, anno: 1993,
pagine: 403 - 408
SICI:
0031-4005(1993)92:3<403:EAOTIH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN LAMBS; NITRIC-OXIDE; BLOOD-FLOW; ARTERIAL;
Keywords:
TOLAZOLINE; MEAN PULMONARY ARTERY PRESSURE; PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN; HYPOXIA; PULMONARY VASCULAR RESISTANCE; SYSTEMIC VASCULAR RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J. Curtis et al., "ENDOTRACHEAL ADMINISTRATION OF TOLAZOLINE IN HYPOXIA-INDUCED PULMONARY-HYPERTENSION", Pediatrics, 92(3), 1993, pp. 403-408

Abstract

Study objective. To compare the pulmonary and systemic vascular responses to intravenously (IV) and endotracheally (ET) administered tolazoline (Tz) in newborn lambs with hypoxia-induced pulmonary hypertension. Design. Randomized, controlled study design. Methods. Twenty lambs, 2 to 7 days of age, were anesthetized, intubated, and surgically catheterized for continuous physiologic monitoring and cardiac output measurements using radiolabeled microspheres. After a postoperative stabilization period, the lambs were ventilated with a hypoxic gas mixture which was titrated to increase mean pulmonary artery pressure (MPAP) 30%to 50% above baseline. Each animal was randomly assigned to receive either IV-Tz (2 mg/kg), ET-Tz (4 mg/kg), or ET-saline (Sal, control group). Results. ET-Tz significantly (P < .05) reduced MPAP, PVRI (pulmonary vascular resistance index), MPAP/mean artery pressure (MAP) and PVRI/systemic vascular resistance index (SVRI), but not SVRI. IV-Tz lowered (P < .05) MPAP, PVRI, and PVRI/SVRI but also produced significant reductions in MAP and SVRI while only transiently decreasing MPAP/MAP. MPAP/MAP and PVRI/SVRI ratios were consistently lower in the ET-Tz animals than either the IV-Tz or ET-Sal animals. Conclusions. Our results suggest that ET-Tz produced a more selective pulmonary vascular response than IV-Tz and may warrant further investigation for potential clinical applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:30:36