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Titolo:
FAST CHROMATOGRAPHIC-SEPARATION OF (-)-MENTHYL CHLOROFORMATE DERIVATIVES OF SOME CHIRAL DRUGS, WITH SPECIAL REFERENCE TO AMLODIPINE, ON POROUS GRAPHITIC CARBON
Autore:
JOSEFSSON M; CARLSSON B; NORLANDER B;
Indirizzi:
LINKOPING UNIV,FAC HLTH SCI,DEPT CLIN PHARMACOL S-58183 LINKOPING SWEDEN LINKOPING UNIV,FAC HLTH SCI,DEPT CLIN PHARMACOL S-58183 LINKOPING SWEDEN
Titolo Testata:
Chromatographia
fascicolo: 3-4, volume: 37, anno: 1993,
pagine: 129 - 132
SICI:
0009-5893(1993)37:3-4<129:FCO(CD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; (+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE; PRECOLUMN DERIVATIZATION; ENANTIOMERS; PERFORMANCE; PHASE;
Keywords:
COLUMN LIQUID CHROMATOGRAPHY; POROUS GRAPHITIC CARBON; CHIRAL RESOLUTION; (-)-MENTHYL CHLOROFORMATE DERIVATIVES; AMLODIPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M. Josefsson et al., "FAST CHROMATOGRAPHIC-SEPARATION OF (-)-MENTHYL CHLOROFORMATE DERIVATIVES OF SOME CHIRAL DRUGS, WITH SPECIAL REFERENCE TO AMLODIPINE, ON POROUS GRAPHITIC CARBON", Chromatographia, 37(3-4), 1993, pp. 129-132

Abstract

Enantiomeric separation of (-)-menthyl chloroformate derivatives of some chiral cardioactive drugs, on porous graphitic carbon (PGC), Hypercarb-S, is described. Capacity and separation factors of derivatives of the calcium channel blockers; amlodipine and UK52.829, the beta-blockers; atenolol, sotalol and propranolol, and mexiletine were studied in different chromatographic systems based on dichloromethane. A high content of a carboxylic acid in the mobile phase was found to decrease the retention and positively affect the stereoselectivity of the derivatives. A mobile phase with dichloromethane, acetonitrile and formic acid gave baseline separation of the enantiomers of amlodipine in less than 8 minutes. Results show that acetic acid and formic acid, may be regarded as strong organic solvents in PGC chromatography with nearly the same elution power as dichloromethane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:09:28