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Titolo: APPARENT DIFFUSIONCOEFFICIENT MAPPING OF EXPERIMENTAL FOCAL CEREBRALISCHEMIA USING DIFFUSIONWEIGHTED ECHOPLANAR IMAGING
Autore: DARDZINSKI BJ; SOTAK CH; FISHER M; HASEGAWA Y; LI LM; MINEMATSU K;
 Indirizzi:
 WORCESTER POLYTECH INST,DEPT BIOMED ENGN WORCESTER MA 01609 WORCESTER POLYTECH INST,DEPT BIOMED ENGN WORCESTER MA 01609 MED CTR CENT MASSACHUSETTS,DEPT NEUROL WORCESTER MA 00000 UNIV MASSACHUSETTS,SCH MED,DEPT RADIOL WORCESTER MA 01605 UNIV MASSACHUSETTS,SCH MED,DEPT NEUROL WORCESTER MA 01605
 Titolo Testata:
 Magnetic resonance in medicine
fascicolo: 3,
volume: 30,
anno: 1993,
pagine: 318  325
 SICI:
 07403194(1993)30:3<318:ADMOEF>2.0.ZU;2L
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 INTRAVOXEL INCOHERENT MOTION; RESTRICTED DIFFUSION; STIMULATED ECHOES; T2WEIGHTED MRI; RATS; SPIN; REPERFUSION; ANISOTROPY; PERFUSION; TISSUES;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 31
 Recensione:
 Indirizzi per estratti:



 Citazione:
 B.J. Dardzinski et al., "APPARENT DIFFUSIONCOEFFICIENT MAPPING OF EXPERIMENTAL FOCAL CEREBRALISCHEMIA USING DIFFUSIONWEIGHTED ECHOPLANAR IMAGING", Magnetic resonance in medicine, 30(3), 1993, pp. 318325
Abstract
Diffusionweighted, echoplanar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient (ADC) during experimental focal ischemia in the rat brain following permanent middle cerebral arterial occlusion (MCAO). Sixteen 64 x 64 diffusionweighted EPIs were acquired in 32 s with successively increasing amplitudes of the diffusionsensitive gradient pulses. A linear leastsquares regression algorithm was used to fit 15 of the 16 twodimensional matrices, on a pixelbypixel basis, to solve for the slope from which the ADC value was calculated. The correlation coefficient of the fit, R2, was used tofilter the final ADC maps, and the ADCs were then scaled appropriately to be displayed in a 256 gray level format. Ranges (bins) of 0.05 x 10(3) mm2/s were then grouped and color coded to qualify and quantifythe evolution of ischemia in the MCA territory. The percentage of area in the ischemic and contralateral hemispheres in seven ADC bins werecalculated at 30, 60, and 120 min after MCAO for 10 animals and demonstrated a significant increase in ADC bins below 0.45 x 10(3) mm2/s and a decrease in bins above 0.50 x 10(3) mm2/s over time. The postmortem infarct area, as measured by TTC staining, was highly correlated with the portion of the ischemic hemisphere falling below ADC values of0.55 x 10(3) mm2/s at 2 h after stroke onset. These studies suggest that focally ischemic brain tissue can be quantitatively subdivided according to ADC values and that ADC values below 0.55 x 10(3) mm2/s2 hfollowing ischemia highly predict infarction in a rat permanent occlusion stroke model.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:50:08