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Titolo:
APPARENT DIFFUSION-COEFFICIENT MAPPING OF EXPERIMENTAL FOCAL CEREBRAL-ISCHEMIA USING DIFFUSION-WEIGHTED ECHO-PLANAR IMAGING
Autore:
DARDZINSKI BJ; SOTAK CH; FISHER M; HASEGAWA Y; LI LM; MINEMATSU K;
Indirizzi:
WORCESTER POLYTECH INST,DEPT BIOMED ENGN WORCESTER MA 01609 WORCESTER POLYTECH INST,DEPT BIOMED ENGN WORCESTER MA 01609 MED CTR CENT MASSACHUSETTS,DEPT NEUROL WORCESTER MA 00000 UNIV MASSACHUSETTS,SCH MED,DEPT RADIOL WORCESTER MA 01605 UNIV MASSACHUSETTS,SCH MED,DEPT NEUROL WORCESTER MA 01605
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 3, volume: 30, anno: 1993,
pagine: 318 - 325
SICI:
0740-3194(1993)30:3<318:ADMOEF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVOXEL INCOHERENT MOTION; RESTRICTED DIFFUSION; STIMULATED ECHOES; T2-WEIGHTED MRI; RATS; SPIN; REPERFUSION; ANISOTROPY; PERFUSION; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Dardzinski et al., "APPARENT DIFFUSION-COEFFICIENT MAPPING OF EXPERIMENTAL FOCAL CEREBRAL-ISCHEMIA USING DIFFUSION-WEIGHTED ECHO-PLANAR IMAGING", Magnetic resonance in medicine, 30(3), 1993, pp. 318-325

Abstract

Diffusion-weighted, echo-planar imaging (EPI) was used to map regional changes in the apparent diffusion coefficient (ADC) during experimental focal ischemia in the rat brain following permanent middle cerebral arterial occlusion (MCAO). Sixteen 64 x 64 diffusion-weighted EPIs were acquired in 32 s with successively increasing amplitudes of the diffusion-sensitive gradient pulses. A linear least-squares regression algorithm was used to fit 15 of the 16 two-dimensional matrices, on a pixel-by-pixel basis, to solve for the slope from which the ADC value was calculated. The correlation coefficient of the fit, R2, was used tofilter the final ADC maps, and the ADCs were then scaled appropriately to be displayed in a 256 gray level format. Ranges (bins) of 0.05 x 10(-3) mm2/s were then grouped and color coded to qualify and quantifythe evolution of ischemia in the MCA territory. The percentage of area in the ischemic and contralateral hemispheres in seven ADC bins werecalculated at 30, 60, and 120 min after MCAO for 10 animals and demonstrated a significant increase in ADC bins below 0.45 x 10(-3) mm2/s and a decrease in bins above 0.50 x 10(-3) mm2/s over time. The postmortem infarct area, as measured by TTC staining, was highly correlated with the portion of the ischemic hemisphere falling below ADC values of0.55 x 10(-3) mm2/s at 2 h after stroke onset. These studies suggest that focally ischemic brain tissue can be quantitatively subdivided according to ADC values and that ADC values below 0.55 x 10(-3) mm2/s2 hfollowing ischemia highly predict infarction in a rat permanent occlusion stroke model.

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Documento generato il 22/09/20 alle ore 07:50:08