Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FAST NA-23 MAGNETIC-RESONANCE-IMAGING OF ACUTE REPERFUSED MYOCARDIAL-INFARCTION - POTENTIAL TO ASSESS MYOCARDIAL VIABILITY
Autore:
KIM RJ; LIMA JAC; CHEN EL; REEDER SB; KLOCK FJ; ZERHOUNI EA; JUDD RM;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,FEINBERG CARDIOVASC RES INST,303 E CHICAGO AVE,TARRY 12-703 CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,FEINBERG CARDIOVASC RES INST CHICAGO IL 60611 JOHNS HOPKINS MED INST BALTIMORE MD 21205 UNIV PENN PHILADELPHIA PA 19104
Titolo Testata:
Circulation
fascicolo: 7, volume: 95, anno: 1997,
pagine: 1877 - 1885
SICI:
0009-7322(1997)95:7<1877:FNMOAR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT-HEART; INTRACELLULAR SODIUM; SHIFT-REAGENTS; NMR; ISCHEMIA; IMAGES; FLOW; ENHANCEMENT; RELAXATION; TISSUE;
Keywords:
MAGNETIC RESONANCE IMAGING; MYOCARDIUM; INFARCTION; SODIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Kim et al., "FAST NA-23 MAGNETIC-RESONANCE-IMAGING OF ACUTE REPERFUSED MYOCARDIAL-INFARCTION - POTENTIAL TO ASSESS MYOCARDIAL VIABILITY", Circulation, 95(7), 1997, pp. 1877-1885

Abstract

Background The ability of the myocyte to maintain an ionic concentration gradient is perhaps the best indication of myocardial viability. We studied the relationship of Na-23 MRI intensity to viability and explored the potential of fast-imaging techniques to reduce Na-23 imagingtimes in rabbits and dogs. Methods and Results Eighteen rabbits underwent in situ coronary artery occlusion and reperfusion. The hearts were then either imaged following isolation and perfusion with cardioplegic solution (n=6), imaged in vivo (n=6), or analyzed for Na-23 contentand relaxation times (n=12). Normal rabbits (n=6) and dogs (n=4) wereimaged to examine the effect of animal size on Na-23 image quality. Na-23 imaging times were 7, 11, and 4 minutes for isolated rabbits, in vivo rabbits, and in vivo dogs, respectively. Infarcted, reperfused regions, identified by triphenyltetrazolium chloride staining, showed a significant elevation in Na-23 image intensity compared with viable regions (isolated, 42+/-5%, P<.02; in vivo, 95+/-6%, P<.001), consistentwith increased tissue sodium content. Similarly, Na-23 MR spectroscopy showed that [Na+] was higher in nonviable than viable myocardium (isolated, 99+/-4 versus 61+/-2 mmol/L; in vivo, 91+/-2 versus 38+/-1 mmol/L; P<.001 for both). Image signal-to-noise ratios were higher in dogs than rabbits despite shorter imaging limes, primarily due to larger voxels. Conclusions Following acute infarction with reperfusion, a regional increase in Na-23 MR image intensity is associated with nonviable myocardium. Fast gradient-echo imaging techniques reduce Na-23 imaging times to a few minutes, suggesting that Na-23 MR imaging has the potential to become a useful experimental and clinical tool.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:51:37