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Titolo:
THE ABILITIES OF 5-HT(3)RECEPTOR ANTAGONIST ICS 205-930 TO INHIBIT ALCOHOL PREFERENCE AND WITHDRAWAL SEIZURES IN RATS
Autore:
KOSTOWSKI W; DYR W; KRZASCIK P;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,SOBIESKIEGO 1-9 WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 5, volume: 10, anno: 1993,
pagine: 369 - 373
SICI:
0741-8329(1993)10:5<369:TAO5AI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NEUROTRANSMISSION; BRAIN NOREPINEPHRINE; ETHANOL-CONSUMPTION; SEROTONIN RECEPTORS; 5-HT3 RECEPTORS; BLOCKADE; IDENTIFICATION; SERTRALINE; ACCUMBENS; 8-OH-DPAT;
Keywords:
5-HT(3)RECEPTOR AND ETHANOL; 5-HT(3)ANTAGONISTS; ICS 205-930; ETHANOL PREFERENCE; ETHANOL INTAKE; AUDIOGENIC SEIZURE RESPONSE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
W. Kostowski et al., "THE ABILITIES OF 5-HT(3)RECEPTOR ANTAGONIST ICS 205-930 TO INHIBIT ALCOHOL PREFERENCE AND WITHDRAWAL SEIZURES IN RATS", Alcohol, 10(5), 1993, pp. 369-373

Abstract

Recent evidence suggests that central 5-HT3 are intimately involved in the ethanol (ETOH) dependence mechanism. In the present study we observed the effects of the 5-HT3 receptor antagonist ICS 205-930 on audiogenic seizure response (ASR) in ETOH-withdrawn rats and on ETOH intake and preference. Low doses of ICS 205-930 (0.001 mg/kg), but not higher doses (0.1 mg/kg), markedly reduced both ASR and ETOH intake in a high preference group of animals. The possible mechanism of different effects of low and high drug doses is discussed.

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Documento generato il 02/07/20 alle ore 22:26:56