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Titolo:
COMPARISON OF THE EFFECTS OF AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR AND A CALCIUM-ANTAGONIST IN HYPERTENSIVE, MACROPROTEINURIC DIABETIC-PATIENTS - A RANDOMIZED DOUBLE-BLIND-STUDY
Autore:
ODONNELL MJ; ROWE BR; LAWSON N; HORTON A; GYDE OH; BARNETT AH;
Indirizzi:
E BIRMINGHAM DIST GEN HOSP,UNDERGRAD TEACHING CTR,BORDESLEY GREEN E BIRMINGHAM B9 5ST W MIDLANDS ENGLAND UNIV BIRMINGHAM,DEPT MED BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
Journal of human hypertension
fascicolo: 4, volume: 7, anno: 1993,
pagine: 333 - 339
SICI:
0950-9240(1993)7:4<333:COTEOA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Odonnell et al., "COMPARISON OF THE EFFECTS OF AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR AND A CALCIUM-ANTAGONIST IN HYPERTENSIVE, MACROPROTEINURIC DIABETIC-PATIENTS - A RANDOMIZED DOUBLE-BLIND-STUDY", Journal of human hypertension, 7(4), 1993, pp. 333-339

Abstract

The objective of this study was to compare the effects of an angiotensin converting enzyme inhibitor, lisinopril, with those of a calcium blocker, nifedipine, on BP control and renal function, in a prospectiverandomised double-blind, double-dummy trial lasting 19 weeks in patients with diabetic nephropathy. We enrolled 28 diabetic patients with hypertension and macroproteinuria from the out-patient diabetic-renal clinic. The antihypertensive treatment consisted of lisinopril or nifedipine, and their effect on arterial BP, urinary albumin excretion, glomerular filtration rate, and renal blood flow were measured. BPs at entry were 166/99 (SD 23/9) mmHg for the lisinopril group and 165/99(21/7) mmHg for the nifedipine group. BPs fell to 143/88 (17/13) mmHg for the lisinopril group and 148/85(25/10) mmHg for the nifedipine group at the end of the study. The albumin excretion rate fell in the lisinopril group from 738.7 (635.2)/mug/min to 644.6 (965.2) mug/min and rosein the nifedipine group from 981.2 (1022.2) mug/min to 1072.5 (908.5)mug/min (P = NS). Glomerular filtration rates fell from 105.2 (57.5) ml/min per 1.73 m2 to 72.1 (39.4) ml/min per 1.73 m2 in the lisinoprilgroup and from 109.9 (50.0) ml/min per 1.73 m2 to 82.9 (53.9) ml/min per 1.73 m2 in the nifedipine treated group. Renal blood flow fell from 446.8 (217.9) ml/min per 1.73 m2 to 435.1 (243.3) ml/min per 1.73 m2for the lisinopril group and from 473.0 (216.4) ml/min per 1.73 m2 to419.0 (278.6) ml/min per 1.73 m2 for the nifedipine group. Differences between the groups were not significant. The filtration fraction fell from 0.44 (0.14) to 0.31 (0.12) in the lisinopril group and from 0.43 (0.14) to 0.38 (0.17) in the nifedipine treated group. Antihypertensive treatment with lisinopril or nifedipine is equally effective in lowering BP in patients with diabetic nephropathy. Urinary albumin excretion showed a tendency to fall in the lisinopril treated group and to increase in the nifedipine treated group. Both drugs produced similar effects on glomerular filtration rate and renal plasma flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:48:14