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Titolo:
NEVIRAPINE SYNERGISTICALLY INHIBITS HIV-1 REPLICATION IN COMBINATION WITH ZIDOVUDINE, INTERFERON OR CD4 IMMUNOADHESIN
Autore:
KOUP RA; BREWSTER F; GROB P; SULLIVAN JL;
Indirizzi:
373 PLANTAT ST,SUITE 318 WORCESTER MA 01605 UNIV MASSACHUSETTS,SCH MED,DEPT PEDIAT WORCESTER MA 01605 UNIV MASSACHUSETTS,SCH MED,PROGRAM MOLEC MED WORCESTER MA 01605 BOEHRINGER INGELHEIM PHARMACEUT INC RIDGEFIELD CT 00000
Titolo Testata:
AIDS
fascicolo: 9, volume: 7, anno: 1993,
pagine: 1181 - 1184
SICI:
0269-9370(1993)7:9<1181:NSIHRI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE INHIBITORS; RECOMBINANT SOLUBLE CD4; HTLV-III; INVITRO; RESISTANT; INFECTIVITY; 3'-AZIDO-3'-DEOXYTHYMIDINE; 2',3'-DIDEOXYINOSINE; DERIVATIVES;
Keywords:
HIV-1; ANTIVIRAL; COMBINATION CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Koup et al., "NEVIRAPINE SYNERGISTICALLY INHIBITS HIV-1 REPLICATION IN COMBINATION WITH ZIDOVUDINE, INTERFERON OR CD4 IMMUNOADHESIN", AIDS, 7(9), 1993, pp. 1181-1184

Abstract

Objective: To determine whether synergistic inhibition of HIV-1 replication would result from the in vitro use of nevirapine in combinationwith zidovudine, interferon (IFN)-alpha 2C, and CD4 immunoadhesin. Design and methods: The non-nucleoside reverse transcriptase inhibitor nevirapine (formerly BI-RG-587) was tested in combination with the other antiretroviral agents. Assays were performed on stimulated peripheral blood lymphocytes infected with HIV-1. Virus replication was assessed by the release of viral p24 antigen into culture supernatants. The median-effect principle was used to assess for synergistic interactionsof the combined agents. Results: Zidovudine, IFN-alpha 2C and CD4 immunoadhesin, when used in combination with nevirapine, synergistically inhibited HIV-1 replication in human peripheral blood lymphocytes compared with each agent used alone. Some analyses were also consistent with additive effects, but antagonism was not noted. Conclusion: These in vitro findings provide a scientific basis for future trials with similar drug combinations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:09:03