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Titolo:
MEDIAL VESTIBULAR NUCLEUS IN THE GUINEA-PIG - APAMIN-INDUCED RHYTHMICBURST FIRING - AN IN-VITRO AND IN-VIVO STUDY
Autore:
DEWAELE C; SERAFIN M; KHATEB A; YABE T; VIDAL PP; MUHLETHALER M;
Indirizzi:
CNRS,PHYSIOL NEUROSENSORIELLE LAB,15 RUE ECOLE MED F-75270 PARIS 06 FRANCE CMU,DEPT PHYSIOL CH-1211 GENEVA SWITZERLAND
Titolo Testata:
Experimental Brain Research
fascicolo: 2, volume: 95, anno: 1993,
pagine: 213 - 222
SICI:
0014-4819(1993)95:2<213:MVNITG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; INTRINSIC MEMBRANE-PROPERTIES; CONTAINING NEURONS INVITRO; CENTRAL-NERVOUS-SYSTEM; BRAIN-STEM SLICES; POTASSIUM CURRENT; OSCILLATORY ACTIVITY; NEOCORTICAL NEURONS; FICTIVE LOCOMOTION; HIPPOCAMPAL SLICE;
Keywords:
CALCIUM-ACTIVATED POTASSIUM CHANNELS; HEAD OSCILLATIONS; EYE OSCILLATIONS; ELECTROGENIC SODIUM PUMP; GUINEA-PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
C. Dewaele et al., "MEDIAL VESTIBULAR NUCLEUS IN THE GUINEA-PIG - APAMIN-INDUCED RHYTHMICBURST FIRING - AN IN-VITRO AND IN-VIVO STUDY", Experimental Brain Research, 95(2), 1993, pp. 213-222

Abstract

In a previous in vitro study, we have shown that guinea-pig medial vestibular nucleus neurons (MVNn) can be grouped into two main cell types based on their intrinsic membrane properties. Subsequent in vivo andin vitro studies demonstrated that these neurons are endowed with N-methyl-D-aspartate (NMDA) receptors and that NMDA induces rhythmic bursts in B MVNn. We now report the occurrence of rhythmic bursts in B MVNn (and in the subclass of B+LTS MVNn) which are induced by long-lasting perfusion of either apamin, a selective blocker of one type of Ca2+-dependent K+ conductance (SK channels), or by a high Mg2+/low Ca2+ artificial cerebrospinal fluid. Apamin-induced bursts were studied in vitro in brainstem slices, and in vivo in the alert unrestrained guinea-pig. In vitro, intracellular recordings demonstrated that the frequencyof the bursts was voltage dependent. These bursts were insensitive toD-2-amino-5-phosphopentanoic acid but could be abolished by tetrodotoxin or blocked by the bath application of 20-50 muM of ouabain, a blocker of the sodium pump. In the in vivo preparation, unilateral infusion of apamin into the vestibular nuclei induced oscillatory head and eye movements. Our data show that the blockade of a Ca2+-activated K+ conductance may switch, in vitro and probably in vivo, the B MVNn firingpattern from a regular to a bursting firing pattern.

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Documento generato il 07/07/20 alle ore 12:27:36