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Titolo:
POPULATION FREQUENCIES OF THE AL ALLELE AT THE DOPAMINE D2 RECEPTOR LOCUS
Autore:
BARR CL; KIDD KK;
Indirizzi:
YALE UNIV,SCH MED,DEPT GENET,333 CEDAR ST NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT GENET,333 CEDAR ST NEW HAVEN CT 06510
Titolo Testata:
Biological psychiatry
fascicolo: 4, volume: 34, anno: 1993,
pagine: 204 - 209
SICI:
0006-3223(1993)34:4<204:PFOTAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA POLYMORPHISMS; SEVERE ALCOHOLISM; GENE; ASSOCIATION; MARKERS; DRD2; RFLP;
Keywords:
DOPAMINE D2 RECEPTOR LOCUS (DRD2); ALCOHOLISM; AL ALLELE; DNA POLYMORPHISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Barr e K.K. Kidd, "POPULATION FREQUENCIES OF THE AL ALLELE AT THE DOPAMINE D2 RECEPTOR LOCUS", Biological psychiatry, 34(4), 1993, pp. 204-209

Abstract

The reported association of a polymorphic allele at the dopamine D2 receptor locus (DRD2) and alcoholism has recently been the focus of considerable interest and controversy. Evidence both for and against an association of the A1 allele of the TaqI A system have been reported. One of the inconsistencies in these studies is the frequency of the A1 allele in the controls. We undertook this study to determine the frequencies of the DRD2 A1 allele in different populations. The frequency of the DRD2 A1 allele was studied in 381 unrelated people from 16 different populations. On a global scale the frequency of the A1 allele wasfound to be dramatically different among the populations studied, from as low as 0.09 to as high as 0.75. Because of these significant differences an association study with this polymorphism must carefully control for ethnic origin of subjects and the results must be evaluated with caution.

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Documento generato il 06/04/20 alle ore 05:35:18