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Titolo:
THE EARLIEST HISTOPATHOLOGICAL RESPONSE TO HYPOBARIC HYPOXIA IN RABBITS IN THE RIFUGIO TORINO (3370-M) ON MONTE BIANCO
Autore:
SMITH P; HEATH D; WILLIAMS D; BENCINI C; PULERA N; GIUNTINI C;
Indirizzi:
UNIV LIVERPOOL,DEPT PATHOL,POB 147 LIVERPOOL L69 3BX ENGLAND UNIV PISA,RESP PATHOPHYSIOL UNIT I-56100 PISA ITALY
Titolo Testata:
Journal of pathology
fascicolo: 4, volume: 170, anno: 1993,
pagine: 485 - 491
SICI:
0022-3417(1993)170:4<485:TEHRTH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID-BODIES; PULMONARY VASCULATURE; HIGH-ALTITUDE; RIGHT VENTRICLE; BODY; RAT; RECOVERY;
Keywords:
RABBIT; HYPOXIA; PULMONARY VASCULATURE; CAROTID BODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P. Smith et al., "THE EARLIEST HISTOPATHOLOGICAL RESPONSE TO HYPOBARIC HYPOXIA IN RABBITS IN THE RIFUGIO TORINO (3370-M) ON MONTE BIANCO", Journal of pathology, 170(4), 1993, pp. 485-491

Abstract

Twelve Dutch rabbits were kept on Monte Bianco at an altitude of 3370m. Half of the animals were killed after 3 months, the remainder after 6 months, and a further six animals maintained at sea-level acted ascontrols. The carotid bodies of all the rabbits were processed for light and electron microscopy and examined qualitatively and quantitatively. The lungs were processed for light microscopical assessment of small pulmonary arterial vessels; the thickness of the pulmonary trunks and aortas were measured; and the hearts were dissected to obtain ratios of the ventricular weight. There was a slight increase in the rightventricular weight in the hypoxic rabbits but no change in the thickness of the pulmonary trunk compared with that of the aorta. In particular, there was no hypoxic remodelling of the pulmonary vasculature such as muscularization of pulmonary arterioles or intimal longitudinal muscle in pulmonary arteries. The earliest histopathological response to hypoxia occurred in the carotid bodies in the form of an increase inthe count of the dark variant of chief cell after 3 months which returned to normal after 6 months. It is concluded that the carotid body of the rabbit responds with a change in its population of dark chief cells to a level of hypoxia which is insufficient to affect the pulmonary arterioles. Changes in the cardiopulmonary system can no longer be considered to be the earliest histopathological response to hypobaric hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 18:54:01