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Titolo:
EFFECT OF HEPARIN AND A LOW-MOLECULAR-WEIGHT HEPARINOID ON PAF-INDUCED AIRWAY RESPONSES IN NEONATALLY IMMUNIZED RABBITS
Autore:
SASAKI M; HERD CM; PAGE CP;
Indirizzi:
KINGS COLL LONDON,DEPT PHARMACOL,MANRESA RD LONDON SW3 6LX ENGLAND KINGS COLL LONDON,DEPT PHARMACOL,MANRESA RD LONDON SW3 6LX ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 110, anno: 1993,
pagine: 107 - 112
SICI:
0007-1188(1993)110:1<107:EOHAAL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BRONCHIAL HYPERRESPONSIVENESS; PLATELET-ACTIVATING FACTOR; ANTIGEN CHALLENGE; GUINEA-PIGS; ASTHMA; INHIBITION; EOSINOPHIL; ANTICOAGULANT; ACCUMULATION; ANTAGONIST;
Keywords:
HEPARIN; LOW-MOLECULAR WEIGHT HEPARIN; PAF; AIRWAYS; INFLAMMATION; AIRWAY HYPERRESPONSIVENESS; NEONATALLY IMMUNIZED RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Sasaki et al., "EFFECT OF HEPARIN AND A LOW-MOLECULAR-WEIGHT HEPARINOID ON PAF-INDUCED AIRWAY RESPONSES IN NEONATALLY IMMUNIZED RABBITS", British Journal of Pharmacology, 110(1), 1993, pp. 107-112

Abstract

1 We have investigated the effect of an unfractionated heparin preparation, a low-molecular weight heparinoid (Org 10172) and the polyanionic molecule polyglutamic acid against PAF-induced airway hyperresponsiveness and pulmonary cell infiltration in neonatally immunized rabbitsin vivo. 2 Exposure of neonatally immunized rabbits to aerosolized platelet activating factor(PAF) (80 mug ml-1 for 60 min) elicited an increase in airway responsiveness to inhaled histamine 24 h and 72 h following challenge which was associated with an infiltration of inflammatory cells into the airways, as assessed by bronchoalveolar lavage (BAL). 3 A significant increase in the total numbers of cells recovered from BAL fluid was associated with significantly increased cell numbers of neutrophils, eosinophils and mononuclear cells 24 h following PAF exposure. The numbers of eosinophils and neutrophils in the airways remained elevated 72 h after challenge. 4 The intravenous administation of an unfractionated preparation of heparin (100 units kg-1) or Org 10172 (I 00 mug kg-1) 30 min prior to PAF exposure significantly inhibited the airway hyperresponsiveness induced by PAF, 24 h and 72 h following challenge. PAF-induced hyperresponsiveness was not significantly affected by prior intravenous administration of polyglutamic acid (100 mug kg-1). 5 The intravenous administration of unfractionated heparin (100 units kg-1), Org 10172 (100 mug kg-1) or polyglutamic acid (100 mug kg-1) 30 min prior to PAF exposure significantly inhibited the expected increase in total cell infiltration. 6 This study shows that unfractionated heparin and a low-molecular weight heparinoid, Org 10172, are capable of inhibiting both the airway hyperresponsiveness and pulmonary cell infiltration induced by PAF in the rabbit.

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Documento generato il 26/09/20 alle ore 02:19:40