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Titolo:
DESENSITIZATION OF RAT CARDIOMYOCYTE ADENYLYL-CYCLASE STIMULATION BY PLASMA OF NORADRENALINE-TREATED PATIENTS WITH SEPTIC SHOCK
Autore:
REITHMANN C; HALLSTROM S; PILZ G; KAPSNER T; SCHLAG G; WERDAN K;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 1,DEPT MED 1,MARCHIONINISTR15 W-8000 MUNICH 70 GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT MED INFORMAT BIOMETRY & EPIDEMIOL W-8000 MUNICH 70 GERMANY LUDWIG BOLTZMANN INST EXPTL & CLIN TRAUMATOL VIENNA AUSTRIA
Titolo Testata:
Circulatory shock
fascicolo: 1, volume: 41, anno: 1993,
pagine: 48 - 59
SICI:
0092-6213(1993)41:1<48:DORCAS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN ALPHA-SUBUNITS; INDUCED UP-REGULATION; HEART MUSCLE-CELLS; NOREPINEPHRINE THERAPY; CARE MEDICINE; APACHE-II; GI-ALPHA; SEPSIS; FAILURE; TOLERANCE;
Keywords:
NORADRENALINE; BETA-ADRENOCEPTOR STIMULATION; INHIBITORY G-PROTEIN; SEPTIC SHOCK; ISOPROTERENOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C. Reithmann et al., "DESENSITIZATION OF RAT CARDIOMYOCYTE ADENYLYL-CYCLASE STIMULATION BY PLASMA OF NORADRENALINE-TREATED PATIENTS WITH SEPTIC SHOCK", Circulatory shock, 41(1), 1993, pp. 48-59

Abstract

The purpose of this study was to test the possibility that the mechanisms of catecholamine-induced desensitization of cardiac beta-adrenoceptor stimulation are modified in septic shock. Exposure of neonatal rat cardiomyocytes for 48 hr to plasma of noradrenaline-treated patientswith septic shock led to a down-regulation of beta-adrenoceptors by 35%, an increase in the level of inhibitory G protein alpha-subunits by60%, and a decrease in isoproterenol-stimulated adenylyl cyclase activity by 50% in membranes prepared from the rat cardiomyocytes. Similaralterations were observed following pretreatment of the cells with plasma of adrenaline-treated patients with cardiogenic shock. In contrast, exposure of the cardiomyocytes to plasma of intensive care patientswithout shock, and to plasma of dopamine-treated patients with septicshock did not induce alterations of the cardiomyocyte adenylyl cyclase system. The dosage of the catecholamines had to be increased within the first two days of treatment in the noradrenaline-treated patients,but not in the dopamine-treated patients with septic shock. Thus, this observed tolerance to noradrenaline in the treatment of septic shockmay, in part, be due to a desensitization of cardiac beta-adrenoceptor stimulation induced by the beta-adrenoceptor stimulatory effect of noradrenaline. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:54:08