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Titolo:
INCREASED 5-HT RELEASE MEDIATES THE ANXIOGENIC RESPONSE DURING BENZODIAZEPINE WITHDRAWAL - A REVIEW OF SUPPORTING NEUROCHEMICAL AND BEHAVIORAL EVIDENCE
Autore:
ANDREWS N; FILE SE;
Indirizzi:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DIV PHARMACOL,PSYCHOPHARMACOL RES UNIT LONDON SEI 9RT ENGLAND UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DIV PHARMACOL,PSYCHOPHARMACOL RES UNIT LONDON SEI 9RT ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 112, anno: 1993,
pagine: 21 - 25
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC DIAZEPAM TREATMENT; RAT-BRAIN; FRONTAL-CORTEX; 5-HYDROXYTRYPTAMINE; BUSPIRONE; INHIBITION; TIANEPTINE; DEPENDENCE; ANXIETY; INVIVO;
Keywords:
ANXIETY; 5-HT RELEASE; 5-HT(1A); 5-HT(3); GABA(B); BENZODIAZEPINE WITHDRAWAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N. Andrews e S.E. File, "INCREASED 5-HT RELEASE MEDIATES THE ANXIOGENIC RESPONSE DURING BENZODIAZEPINE WITHDRAWAL - A REVIEW OF SUPPORTING NEUROCHEMICAL AND BEHAVIORAL EVIDENCE", Psychopharmacology, 112(1), 1993, pp. 21-25

Abstract

This paper reviews the biochemical and behavioural evidence that the increased anxiety that occurs during benzodiazepine withdrawal is caused by increased 5-HT activity. In hippocampal slices taken from rats withdrawn for 24 h from chronic diazepam treatment (2 mg/kg/day for 21 days) there was a significant increase in K+-evoked release of [H-3]5-HT and in Ca-45(2+) uptake and both of these changes were reversed by the GABA(B) agonist, baclofen. Baclofen also reversed the anxiogenic response that is detected on withdrawal from chronic diazepam treatment. Other drugs that reduce 5-HT function (tianeptine which increases 5-HT uptake; buspirone, a 5-HT1A receptor agonist/partial agonist; zacopride, a 5-HT3 receptor antagonist) also reversed this anxiogenic response. Finally, we present data from a group of rats that did not develop tolerance to the anxiolytic effects of diazepam (2 mg/kg), even after 5 weeks treatment. This group failed to show an anxiogenic response on withdrawal from diazepam, nor was there an increase in hippocampal 5-HT release. We discuss the extent to which increased hippocampal 5-HT release can be causally linked to the increased anxiety during benzodiazepine withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:19:03