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Titolo:
LOW VERSUS HIGH PROLACTIN RESPONDERS TO FENFLURAMINE CHALLENGE - MARKER OF BEHAVIORAL-DIFFERENCES IN ADULT MALE CYNOMOLGUS MACAQUES
Autore:
BOTCHIN MB; KAPLAN JR; MANUCK SB; MANN JJ;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,COMPARAT MED CLIN RES CTR,MED CTR BLVD WINSTON SALEM NC 27157 UNIV PITTSBURGH,DEPT PSYCHOL,BEHAV PHYSIOL LAB PITTSBURGH PA 15260 UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,DEPT PSYCHIAT PITTSBURGHPA 15213
Titolo Testata:
Neuropsychopharmacology
fascicolo: 2, volume: 9, anno: 1993,
pagine: 93 - 99
SICI:
0893-133X(1993)9:2<93:LVHPRT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; BINDING-SITES; SUICIDE VICTIMS; ANORECTIC DRUG; FRONTAL-CORTEX; MONKEYS; ATHEROSCLEROSIS; PLASMA; RATS;
Keywords:
AGGRESSION; SEROTONIN; FENFLURAMINE; PROLACTIN; CYNOMOLGUS MACAQUES; SOCIAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Botchin et al., "LOW VERSUS HIGH PROLACTIN RESPONDERS TO FENFLURAMINE CHALLENGE - MARKER OF BEHAVIORAL-DIFFERENCES IN ADULT MALE CYNOMOLGUS MACAQUES", Neuropsychopharmacology, 9(2), 1993, pp. 93-99

Abstract

Prolactin response to acute administration of fenfluramine hydrochloride is considered an indirect assessment of ''net' central serotonergic activity. This study compared behavioral characteristics of adult, male cynomolgus macaques (Macaca fascicularis) having ''low'' or ''high'' prolactin responses to fenfluramine challenge. The subjects were 75animals housed in five-member social groups for 28 months. In month 23, prolactin responses to fenfluramine challenge were evaluated. Observations of specific behaviors (aggressive, submissive, affiliative, and nonsocial) were made three times per week on animals in each social group. The dominance status of each animal within a social group was assessed at weekly intervals. Low prolactin responders had a significantly higher index of ''overt'' aggression (ratio of fights involving physical contact and chasing or lunging/all forms of aggressive behavior) compared to high prolactin responders (p < .03). There were no differences in the dominance status of low and high responders (p = .34). Furthermore, low responders were more socially withdrawn than high responders, as they spent significantly more time alone (passive or neutral state; p < .03) and less time in passive body contact with other animals than high responders (p < .05). These data support the hypothesisthat reduced central serotonergic activity in nonhuman primates is associated with a high level of overt aggression and a low level of positive social interaction.

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Documento generato il 11/07/20 alle ore 04:44:26