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Titolo:
IMMUNOMODULATING EFFECT OF URSODEOXYCHOLIC ACID THERAPY IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS
Autore:
KURKTSCHIEV D; SUBAT S; ADLER D; SCHENTKE KU;
Indirizzi:
MED ACAD CARL GUSTAV CARUS,INNERE MED KLIN,GASTROENTEROL ABT,FETSCHERSTR 74 O-8019 DRESDEN GERMANY
Titolo Testata:
Journal of hepatology
fascicolo: 3, volume: 18, anno: 1993,
pagine: 373 - 377
SICI:
0168-8278(1993)18:3<373:IEOUAT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIPEPTIDYL PEPTIDASE-IV; HUMAN LYMPHOCYTES-T; IMMUNE-SYSTEM;
Keywords:
PRIMARY BILIARY CIRRHOSIS; URSODEOXYCHOLIC ACID THERAPY; DIPEPTIDE PEPTIDASE-IV; INTERLEUKIN-2;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
D. Kurktschiev et al., "IMMUNOMODULATING EFFECT OF URSODEOXYCHOLIC ACID THERAPY IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS", Journal of hepatology, 18(3), 1993, pp. 373-377

Abstract

Peripheral blood lymphocytes of 22 patients with primary biliary cirrhosis under ursodeoxycholic acid therapy were examined for selected lymphocyte activation markers. The percentage of dipeptidyl peptidase IVpositive Peripheral blood lymphocytes of primary biliary cirrhosis patients by using immune- and enzymehistochemical staining was found to be low (5-12%), with healthy controls exhibiting a normal range of 18-27%. After pokeweed mitogen stimulation in vitro the interleukin-2 production by peripheral blood lymphocytes in primary biliary cirrhosis patients was significantly decreased (3.135 pg/ml mean value), comparedto healthy subjects (61.167 pg/ml mean value). After 4-20 weeks ursodeoxycholic acid treatment the dipeptidyl peptidase IV expression and IL-2 production were normalised. These results provide evidence for theimmunomodulating effect of ursodeoxycholic acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:09:26