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Titolo:
HORMONAL-REGULATION OF HEPATITIS-B VIRUS GENE-EXPRESSION - INFLUENCE OF ANDROGEN RECEPTOR
Autore:
BREIDBART S; BURK RD; SAENGER P;
Indirizzi:
MONTEFIORE MED CTR,DEPT PEDIAT,111 E 210TH ST BRONX NY 10467 MONTEFIORE MED CTR,DEPT PEDIAT,111 E 210TH ST BRONX NY 10467 YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR,DEPT OBSTET & GYNECOL BRONX NY 10461
Titolo Testata:
Pediatric research
fascicolo: 3, volume: 34, anno: 1993,
pagine: 300 - 302
SICI:
0031-3998(1993)34:3<300:HOHVG->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ANTIGEN GENE; TRANSGENIC MICE; TESTICULAR FEMINIZATION; 2 LINES; MOUSE; PATHOGENESIS; CHROMOSOME; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S. Breidbart et al., "HORMONAL-REGULATION OF HEPATITIS-B VIRUS GENE-EXPRESSION - INFLUENCE OF ANDROGEN RECEPTOR", Pediatric research, 34(3), 1993, pp. 300-302

Abstract

Adult HBV-transgenic males produce more hepatitis B surface antigen (HBsAg) in serum than females. The difference decreases with castrationand is restored with testosterone replacement. To investigate the contribution of the androgen receptor in this process, HBV-transgenic males were mated with females heterozygous for the testicular feminization mutation (Tfm), an X-linked gene with 90% reduced androgen receptor. A total of 19 phenotypic HBV-transgenic females were studied, of which eight XY(Tfm) females were identified by the presence of Y-chromosome DNA using molecular hybridization. The 11 normal (XX) females had 11.7 +/- 3.5 mug/mL (mean +/- SD) of HBsAg in their serum, whereas the Tfm (XY) females had 17.1 +/- 5.9 gg/mL (p < 0.05). However, the Tfm (XY) females produced less HBsAg than 33 normal (XY) males (41 +/- 12 mug/mL), and the overall ratio of male/female HBsAg levels was reduced: XY/XX = 3 versus XY(Tfm)/XX = 1.5. Although dexamethasone caused an increase in XY(Tfm) and XX mice, testosterone did not increase HBsAg in XY(Tfm). These data indicate that hepatitis B expression as measured by HBsAg levels in this animal model is mediated through an androgen receptor.

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Documento generato il 28/01/21 alle ore 06:59:28