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Titolo:
EXTRACELLULAR 5-HYDROXYTRYPTAMINE CONCENTRATION IN RAT HYPOTHALAMUS AFTER ADMINISTRATION OF FLUOXETINE PLUS L-5-HYDROXYTRYPTOPHAN
Autore:
PERRY KW; FULLER RW;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285 ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 8, volume: 45, anno: 1993,
pagine: 759 - 761
SICI:
0022-3573(1993)45:8<759:E5CIRH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; SEROTONIN UPTAKE; LILLY 110140; UPTAKE INHIBITOR; BRAIN-SEROTONIN; MICRODIALYSIS; SECRETION; NEURONS; PROLACTIN; REUPTAKE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Perry e R.W. Fuller, "EXTRACELLULAR 5-HYDROXYTRYPTAMINE CONCENTRATION IN RAT HYPOTHALAMUS AFTER ADMINISTRATION OF FLUOXETINE PLUS L-5-HYDROXYTRYPTOPHAN", Journal of Pharmacy and Pharmacology, 45(8), 1993, pp. 759-761

Abstract

Fluoxetine (10 mg kg-1, i.p.) caused a three- to fourfold increase inextracellular 5-hydroxytryptamine (5-HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition Of L-5-hydroxytryptophan at 20 or 40 mg kg-1, i.p. doses, magnified the increase in extracellular 5-HT to as much as 16 times basal levels, although these doses of L-5-hydroxytryptophan alone had only small effects on extracellular 5-HT. The increased formation of 5-HT following L-5-hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5-HT caused by uptake inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:42:37