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Titolo:
HOMEORHETIC ACTIONS ON TISSUE PROTEIN-METABOLISM AFTER THE ADMINISTRATION OF RAT GROWTH-HORMONE TO NORMAL RATS
Autore:
DELBARRIO AS; MARTINEZ JA; LARRALDE J;
Indirizzi:
UNIV PAIS VASCO,DEPT NUTR & FOOD SCI E-01007 VITORIA SPAIN UNIV NAVARRA,DEPT PHYSIOL & NUTR E-31008 PAMPLONA SPAIN
Titolo Testata:
Endocrine research
fascicolo: 2-3, volume: 19, anno: 1993,
pagine: 163 - 173
SICI:
0743-5800(1993)19:2-3<163:HAOTPA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC AGONIST; SOMATOMEDIN-C; ANABOLIC ACTIONS; SKELETAL-MUSCLE; BONE; PITUITARY; RECEPTORS; RESPONSES; TURNOVER; ANIMALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Delbarrio et al., "HOMEORHETIC ACTIONS ON TISSUE PROTEIN-METABOLISM AFTER THE ADMINISTRATION OF RAT GROWTH-HORMONE TO NORMAL RATS", Endocrine research, 19(2-3), 1993, pp. 163-173

Abstract

An acute treatment with rat growth hormone (1 mug/g) to intact femalerats produced immediate changes in muscle and bone protein synthesis as well as in muscle protein breakdown, while glucose and glutamate-piruvate transaminase plasma levels were not altered. These effects, apparently, are not mediated by systemic insulin-like growth factor I. Also a long-term treatment with somatotropin (0.1 mug/g/d) for 22 days was performed, in which protein synthesis rates in muscle, liver and bone remained unchanged. However, the growth hormone long-term treatmentinduced a decrease in muscle proteolytic activity and an increase in tibia weight. In this context, this experiment describes, apparently for the first time, the systemic effect of growth hormone in entire female rats. Data suggest that a single dose of rat growth hormone produces immediate changes in tissue protein metabolism, through a direct effect of growth hormone. These effects were not observed after the long-term growth hormone treatment, although these animals showed an increased in tibia proportions.

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Documento generato il 02/07/20 alle ore 18:15:50