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Titolo: QUANTITATIVE SAMEDAY RESTSTRESS TECHNETIUM99MSESTAMIBI SPECT  DEFINITION AND VALIDATION OF STRESS NORMAL LIMITS AND CRITERIA FOR ABNORMALITY
Autore: VANTRAIN KF; AREEDA J; GARCIA EV; COOKE CD; MADDAHI J; KIAT H; GERMANO G; SILAGAN G; FOLKS R; BERMAN DS;
 Indirizzi:
 CEDARS SINAI MED CTR,DEPT IMAGING NUCL MED,8700 BEVERLY BLVD LOS ANGELES CA 90048 CEDARS SINAI MED CTR,DEPT MED,DIV CARDIOL LOS ANGELES CA 90048 UNIV CALIF LOS ANGELES,SCH MED LOS ANGELES CA 90024 EMORY UNIV,SCH MED ATLANTA GA 30322
 Titolo Testata:
 The Journal of nuclear medicine
fascicolo: 9,
volume: 34,
anno: 1993,
pagine: 1494  1502
 SICI:
 01615505(1993)34:9<1494:QSRTS>2.0.ZU;27
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 CORONARYARTERY DISEASE; TL201 MYOCARDIAL SCINTIGRAMS; CLINICALDIAGNOSIS; MULTICENTER TRIAL; TC99M SESTAMIBI; TOMOGRAPHY; EXERCISE; PROBABILITY; INJECTIONS; EMISSION;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 34
 Recensione:
 Indirizzi per estratti:



 Citazione:
 K.F. Vantrain et al., "QUANTITATIVE SAMEDAY RESTSTRESS TECHNETIUM99MSESTAMIBI SPECT  DEFINITION AND VALIDATION OF STRESS NORMAL LIMITS AND CRITERIA FOR ABNORMALITY", The Journal of nuclear medicine, 34(9), 1993, pp. 14941502
Abstract
Gendermatched stress normal limits and criteria for abnormality for reststress Tc99msestamibi sameday myocardial perfusion imaging were developed and validated in 160 patients who were imaged using previously developed optimized acquisition, processing and quantitative protocols. The gendermatched mean and standard deviation of the normal response were calculated using 35 male and 25 female patients with a <5%likelihood of coronary artery disease. Receiveroperating curve analysis using expert visual interpretation as the ''gold standard'' was used to determine the optimal criteria for abnormality detection, in terms of standard deviations from the mean and minimum defect size for each of the four major zones of the polar map, in a pilot population consisting of an additional 35 male and 25 female patients with a varietyof perfusion defects. The optimum standard deviations resulted in thefollowing truepositive/truenegative rates when quantitative resultswere compared to visual analysis for the anterior, septal, lateral, and inferior segments in the combined male and female pilot populations: 84%/86%, 70%/75%, 86%/76% and 69%/76%, respectively. The final criteria were then applied to a prospective population consisting of 33 male and 7 female patients. This analysis resulted in the following truepositive/truenegative rates for overall perfusion abnormalities and abnormalities of the LAD, LCX and RCA vascular territories: 97%/67%, 94%/73%, 73%/90% and 72%/91%, respectively. The optimized Tc99msestamibi stress normal limits and criteria for abnormality correlate well with expert visual interpretation of stress myocardial perfusion defects.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:03:05