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Titolo:
QUANTITATIVE SAME-DAY REST-STRESS TECHNETIUM-99M-SESTAMIBI SPECT - DEFINITION AND VALIDATION OF STRESS NORMAL LIMITS AND CRITERIA FOR ABNORMALITY
Autore:
VANTRAIN KF; AREEDA J; GARCIA EV; COOKE CD; MADDAHI J; KIAT H; GERMANO G; SILAGAN G; FOLKS R; BERMAN DS;
Indirizzi:
CEDARS SINAI MED CTR,DEPT IMAGING NUCL MED,8700 BEVERLY BLVD LOS ANGELES CA 90048 CEDARS SINAI MED CTR,DEPT MED,DIV CARDIOL LOS ANGELES CA 90048 UNIV CALIF LOS ANGELES,SCH MED LOS ANGELES CA 90024 EMORY UNIV,SCH MED ATLANTA GA 30322
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 9, volume: 34, anno: 1993,
pagine: 1494 - 1502
SICI:
0161-5505(1993)34:9<1494:QSRTS->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; TL-201 MYOCARDIAL SCINTIGRAMS; CLINICAL-DIAGNOSIS; MULTICENTER TRIAL; TC-99M SESTAMIBI; TOMOGRAPHY; EXERCISE; PROBABILITY; INJECTIONS; EMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K.F. Vantrain et al., "QUANTITATIVE SAME-DAY REST-STRESS TECHNETIUM-99M-SESTAMIBI SPECT - DEFINITION AND VALIDATION OF STRESS NORMAL LIMITS AND CRITERIA FOR ABNORMALITY", The Journal of nuclear medicine, 34(9), 1993, pp. 1494-1502

Abstract

Gender-matched stress normal limits and criteria for abnormality for rest-stress Tc-99m-sestamibi same-day myocardial perfusion imaging were developed and validated in 160 patients who were imaged using previously developed optimized acquisition, processing and quantitative protocols. The gender-matched mean and standard deviation of the normal response were calculated using 35 male and 25 female patients with a <5%likelihood of coronary artery disease. Receiver-operating curve analysis using expert visual interpretation as the ''gold standard'' was used to determine the optimal criteria for abnormality detection, in terms of standard deviations from the mean and minimum defect size for each of the four major zones of the polar map, in a pilot population consisting of an additional 35 male and 25 female patients with a varietyof perfusion defects. The optimum standard deviations resulted in thefollowing true-positive/true-negative rates when quantitative resultswere compared to visual analysis for the anterior, septal, lateral, and inferior segments in the combined male and female pilot populations: 84%/86%, 70%/75%, 86%/76% and 69%/76%, respectively. The final criteria were then applied to a prospective population consisting of 33 male and 7 female patients. This analysis resulted in the following true-positive/true-negative rates for overall perfusion abnormalities and abnormalities of the LAD, LCX and RCA vascular territories: 97%/67%, 94%/73%, 73%/90% and 72%/91%, respectively. The optimized Tc-99m-sestamibi stress normal limits and criteria for abnormality correlate well with expert visual interpretation of stress myocardial perfusion defects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:03:05