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Titolo:
ENHANCEMENT OF INTERLEUKIN-2 (IL-2) PRODUCTION BY 6 DIFFERENT CYTOKINES - HETEROGENEITY AMONG IL-2 PRODUCING T-CELL CLONES
Autore:
HOLAN V; MINOWADA J;
Indirizzi:
CZECHOSLOVAK ACAD SCI,INST MOLEC GENET,FLEMINGOVO NAM 2 CS-16637 PRAGUE 6 CZECHOSLOVAKIA HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR FUJISAKI OKAYAMA JAPAN
Titolo Testata:
Folia biologica
fascicolo: 1, volume: 39, anno: 1993,
pagine: 1 - 13
SICI:
0015-5500(1993)39:1<1:EOI(PB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN INTERFERON-ALPHA; RECOMBINANT INTERLEUKIN-2; SURFACE RECEPTORS; ENDOTHELIAL-CELLS; GAMMA-INTERFERON; ACTIVATION; BETA; ANTIGEN; IMMUNOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
V. Holan e J. Minowada, "ENHANCEMENT OF INTERLEUKIN-2 (IL-2) PRODUCTION BY 6 DIFFERENT CYTOKINES - HETEROGENEITY AMONG IL-2 PRODUCING T-CELL CLONES", Folia biologica, 39(1), 1993, pp. 1-13

Abstract

The production of interleukin-2 (IL-2) by phytohemagglutinin (PHA)-stimulated human leukemia T cell lines was significantly increased by 6 different cytokines. The most effective cytokines were interleukin-1alpha (IL-1alpha) and IL-1beta; less effective were interferon-alpha (IFN-alpha), tumor necrosis factor-alpha (TNF-alpha), IFN-beta and TNF-beta. The combinations of two cytokines had synergistic or additive effects and increased IL-2 production to a greater extent than either cytokine alone. Other cytokines tested, such as IL-3, IL-4, IL-6, IL-7, IL-8 and IFN-gamma, had no effect on IL-2 production. However, a remarkable heterogeneity in sensitivity to the enhancing effects of the active cytokines was found among the IL-2-producing T cell lines studied. While IL-2 production in the most sensitive cell line, MOLT-16, was increased by all 6 active cytokines, other cell lines responded by increasing IL-2 production to stimulation with only some of the cytokines tested. The production of IL-2 in T cell line H9 was not enhanced by anyof the cytokines used. These results show that several cytokines can increase IL-2 production by having a direct effect on the activated IL-2-producing T cells, but also that the outcome of the regulatory effects of individual cytokines depends considerably upon the individual IL-2-producing T cell clone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:32:28