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Titolo:
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ASSOCIATED WITH BACTERIAL-ENDOCARDITIS - EFFICACY OF ANTIBIOTIC-THERAPY ALONE
Autore:
ORFILA C; LEPERT JC; MODESTO A; GOUDABLE C; SUC JM;
Indirizzi:
CHU RANGUEIL,INSERM,CJF 91-07,1 AVE JEAN POUILHES,BAITMENT L1 F-31052TOULOUSE FRANCE CHU TOULOUSE RANGUEIL,INSERM,U133 TOULOUSE FRANCE CHU TOULOUSE RANGUEIL,SERV NEPHROL TOULOUSE FRANCE
Titolo Testata:
American journal of nephrology
fascicolo: 3, volume: 13, anno: 1993,
pagine: 218 - 222
SICI:
0250-8095(1993)13:3<218:RPGAWB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING IMMUNE-COMPLEXES; INFECTIVE ENDOCARDITIS; PLASMAPHERESIS;
Keywords:
BACTERIAL ENDOCARDITIS; GLOMERULONEPHRITIS; CRESCENTS; ANTIBIOTIC THERAPY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C. Orfila et al., "RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ASSOCIATED WITH BACTERIAL-ENDOCARDITIS - EFFICACY OF ANTIBIOTIC-THERAPY ALONE", American journal of nephrology, 13(3), 1993, pp. 218-222

Abstract

A 65-year-old woman presented rapidly progressive glomerulonephritis with purpura and mitral insufficiency. Blood cultures grew Streptococcus mitis. By light microscopy, the renal biopsy revealed necrotizing glomerulonephritis 56% associated with cellular crescents and tubulointerstitial changes. By immunofluorescence, deposits of IgM and C3 were found to be present in the mesangium. Electron-microscopic study showed subendothelial and intramembranous deposits. Treatment with antibiotics alone resulted in renal recovery with disappearance of proteinuria, circulating immune complexes and cryoglobulinemia. A 2nd renal biopsy, performed after 3 months, showed segmental sclerosis and tubulointerstitial lesions. Eight months after the first hospitalization, cardiac insufficiency occurred. Four years later, a valve replacement was performed. No abnormal serum creatinine, serum creatinine clearance or urinalysis levels were present. These data suggest that rapidly progressive glomerulonephritis associated with bacterial endocarditis may be treated by antibiotics alone and result in normal and stable renal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:10:04