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Titolo:
ENHANCED IN-VITRO GROWTH OF GLOMERULAR CELLS DERIVED FROM RATS WITH IMMUNE-MEDIATED MESANGIAL INJURY
Autore:
HARENDZA SGA; THAISS F; STAHL RAK;
Indirizzi:
UNIV FRANKFURT,DEPT MED,DIV NEPHROL,THEODOR STERN KAI 7 W-6000 FRANKFURT 70 GERMANY UNIV FRANKFURT,DEPT MED,DIV NEPHROL,THEODOR STERN KAI 7 W-6000 FRANKFURT 70 GERMANY
Titolo Testata:
Experimental nephrology
fascicolo: 1, volume: 1, anno: 1993,
pagine: 55 - 61
SICI:
1018-7782(1993)1:1<55:EIGOGC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
GLOMERULAR INJURY; MESANGIAL CELL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S.G.A. Harendza et al., "ENHANCED IN-VITRO GROWTH OF GLOMERULAR CELLS DERIVED FROM RATS WITH IMMUNE-MEDIATED MESANGIAL INJURY", Experimental nephrology, 1(1), 1993, pp. 55-61

Abstract

In order to evaluate whether in vivo immune-mediated lesions in the glomerulus might affect growth of glomerular cells in vitro, we developed a combined in vivo-in vitro approach. An immune-mediated mesangial cell injury was induced in rats by intravenous injection of a rabbit anti-rat thymocyte antiserum (ATS). Beginning at day 1 up to 12 days after ATS, glomeruli were isolated for glomerular cell culture and evaluation of cell growth. Compared with control rats cell growth from nephritic glomeruli was significantly higher at all time points studied. Immunohistologic studies performed revealed that the proliferating cells had characteristics of glomerular mesangial cells. These data demonstrate that mesangial cells derived from nephritic glomeruli have increased growth in vitro compared with cells from normal glomeruli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 02:58:37