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Titolo:
THE ATTACHMENT OF MINICIRCLES TO KINETOPLAST DNA NETWORKS DURING REPLICATION
Autore:
PEREZMORGA DL; ENGLUND PT;
Indirizzi:
UNIV LIBRE BRUXELLES,DEPT BIOL MOLEC,RUE CHEVAUX 67 B-1640 RHODE ST GENESE BELGIUM JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM BALTIMORE MD 21205
Titolo Testata:
Cell
fascicolo: 4, volume: 74, anno: 1993,
pagine: 703 - 711
SICI:
0092-8674(1993)74:4<703:TAOMTK>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITHIDIA-FASCICULATA; 2 SITES; TRYPANOSOMES; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Perezmorga e P.T. Englund, "THE ATTACHMENT OF MINICIRCLES TO KINETOPLAST DNA NETWORKS DURING REPLICATION", Cell, 74(4), 1993, pp. 703-711

Abstract

Kinetoplast DNA (kDNA), the trypanosomatid mitochondrial DNA, is a network containing several thousand interlocked minicircles. During kDNAsynthesis, minicircles dissociate from the network, and after replication their progeny reattach to the network periphery. Using electron microscopy autoradiography, we found that newly synthesized H-3-labeledminicircles, after short labeling periods, are concentrated in two peripheral zones on opposite sides of the network. These must be minicircle attachment sites, adjacent to the two diametrically opposed complexes of replication proteins observed previously. From the pattern of radiolabeling during longer pulses, we reached the unexpected conclusion that minicircle attachment around the entire network periphery may be due to a relative movement of the kinetoplast and the two complexes. The kinetoplast probably rotates between two fixed complexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:42:59