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Titolo:
LOCALIZATION OF DRUG-RELEASE SITES FROM AN ORAL SUSTAINED-RELEASE FORMULATION OF 5-ASA (PENTASA(R)) IN THE GASTROINTESTINAL-TRACT USING GAMMA-SCINTIGRAPHY
Autore:
HARDY JG; HARVEY WJ; SPARROW RA; MARSHALL GB; STEED KP; MACARIOS M; WILDING IR;
Indirizzi:
NORD MERRELL DOW RES INC,POB 1030,ST MARTIN BRANCH LAVAL H7S 2A4 PQ CANADA NORD MERRELL DOW RES INC,POB 1030,ST MARTIN BRANCH LAVAL H7S 2A4 PQ CANADA PHARMACEUT PROFILES LTD NOTTINGHAM ENGLAND
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 8, volume: 33, anno: 1993,
pagine: 712 - 718
SICI:
0091-2700(1993)33:8<712:LODSFA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-AMINOSALICYLIC ACID; HEALTHY-VOLUNTEERS; TRANSIT; SALICYLAZOSULFAPYRIDINE; ABSORPTION; OLSALAZINE; BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Hardy et al., "LOCALIZATION OF DRUG-RELEASE SITES FROM AN ORAL SUSTAINED-RELEASE FORMULATION OF 5-ASA (PENTASA(R)) IN THE GASTROINTESTINAL-TRACT USING GAMMA-SCINTIGRAPHY", Journal of clinical pharmacology, 33(8), 1993, pp. 712-718

Abstract

Release of 5-ASA from a sustained release formulation (Pentasa(R), Ferring A/S, Copenhagen, Denmark) was monitored with plasma sampling forup to 24 hours in nine volunteers under both fasted and fed conditions. Drug absorption was correlated with location of the sustained-release microgranules in the gastrointestinal tract by gamma scintigraphy. Disintegration of the labeled tablet preparation occurred in the stomach within 20 minutes and acetylated 5-ASA was detectable in the plasmaless than 60 minutes after ingestion. No significant differences weredetected in either transit times through the small intestine, peak plasma acetylated 5-ASA concentration or lag time to absorption between fasted and fed individuals. Peak plasma concentration of acetylated 5-ASA usually occurred when the microgranules were present in the small intestine or ascending colon. The pharmacoscintigraphic study confirmed that 5-ASA release from the formulation occurred throughout the gastrointestinal tract, and that food effects on the in vivo behavior of the preparation were minimal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:22:04