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Titolo:
THE INFLUENCE OF INTRAVENOUS ANESTHETICS ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTION
Autore:
KRUMHOLZ W; DEMEL C; JUNG S; MEUTHEN G; HEMPELMANN G;
Indirizzi:
UNIV GIESSEN,ANAESTHESIOL & OPERAT INTENS MED ABT,KLINIKSTR 29 W-6300GIESSEN GERMANY
Titolo Testata:
Canadian journal of anaesthesia
fascicolo: 8, volume: 40, anno: 1993,
pagine: 770 - 774
SICI:
0832-610X(1993)40:8<770:TIOIAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIC AGENTS; CHEMI-LUMINESCENCE; HUMAN-GRANULOCYTES; INVITRO;
Keywords:
ANESTHETICS, INTRAVENOUS, DROPERIDOL; FLUNITRAZEPAM; METHOHEXITONE; BLOOD, LEUKOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W. Krumholz et al., "THE INFLUENCE OF INTRAVENOUS ANESTHETICS ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTION", Canadian journal of anaesthesia, 40(8), 1993, pp. 770-774

Abstract

Polymorphonuclear leukocytes (PMNL) play a vital role in the defence against invading bacteria. It is known that some anaesthetics inhibit PMNL function and, thus, possibly enhance perioperative infection. We investigated the effect of methohexitone, flunitrazepam, and droperidol on three bactericidal PMNL functions, i. e., superoxide anion production, hydrogen peroxide generation, and activity of released myeloperoxidase, in vitro Approved photometrical assays were used Superoxide anion was measured by the reduction of cytochrome C, hydrogen peroxide by the horse radish peroxidase catalysed oxidation of phenol red and myeloperoxidase by the turnover of 2,2'-azino-di(3-ethylbenzthiazoline) sulfonic acid. Methohexitone (P less-than-or-equal-to 0.001) and flunitrazepam (P less-than-or-equal-to 0.01) inhibited superoxide anion production, and methohexitone (P less-than-or-equal-to 0.01) reduced hydrogen Peroxide generation but only at concentrations beyond clinical relevance. Droperidol did not cause any alteration of the PMNL functionstested Consequently, it seems unlikely that the usual doses of methohexitone, flunitrazepam, or droperidol promote bacterial infections in vivo by impairing the activity of myeloperoxidase or by inhibiting thegeneration of superoxide anion or hydrogen peroxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 15:21:19