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Titolo:
EFFECT OF CHOLESTEROL OXIDES ON PROSTACYCLIN PRODUCTION AND PLATELET-ADHESION
Autore:
PENG SK; HU B; PENG AY; MORIN RJ;
Indirizzi:
UCLA,SCH MED,HARBOR MED CTR,DEPT PATHOL TORRANCE CA 90509 UCLA,SCH MED,HARBOR MED CTR,MED LAB TORRANCE CA 90509
Titolo Testata:
Artery
fascicolo: 3, volume: 20, anno: 1993,
pagine: 122 - 134
SICI:
0098-6127(1993)20:3<122:EOCOOP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; OXIDATION DERIVATIVES; PROSTAGLANDIN-I2; INHIBITION; GENERATION; ARTERIES; INVITRO;
Keywords:
CHOLESTEROL OXIDES; PROSTACYCLIN; ENDOTHELIAL CELL; PLATELET ADHESION; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Peng et al., "EFFECT OF CHOLESTEROL OXIDES ON PROSTACYCLIN PRODUCTION AND PLATELET-ADHESION", Artery, 20(3), 1993, pp. 122-134

Abstract

Prostacyclin (PGI2) is synthesized primarily by endothelial cells, isessential for maintenance of vascular integrity, and may play a role in atherogenesis. Human umbilical vein endothelial cells in culture were incubated with either pure cholesterol, 25-hydroxycholesterol, 7-ketocholesterol, cholesterol 5alpha,6alpha-epoxide or cholestane-3beta,5alpha,6beta-triol at 10 mug/ml culture medium concentration for 12 hours and 24 hours. PGI2 production measured by radio-immunoassay of 6-keto PGF1alpha, the stable metabolite of PGI2 was inhibited by 39.6%, 27.3%, 40.1% and 31.9% after incubation with 25-hydroxycholesterol, 7-ketocholesterol, cholesterol 5alpha, 6alpha-epoxide or cholestane-3beta,5alpha,6beta-triol for 12 hours respectively. Further inhibitory effects were shown after 24 hours of incubation with 25-hydroxycholesterol and 7-ketocholesterol. Platelet adhesion onto endothelial cell monolayers measured by In-111-labeled platelets was enhanced by 104%, 54% and37% after incubation with cholestane-3beta,5alpha,6beta-triol, 25-hydroxycholesterol, and 7-ketocholesterol at 10 mug/ml concentration for 12 hours respectively. Pure cholesterol at the same concentration had no effect on PGI2 production or platelet adhesion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:17:18