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Titolo:
PSYCHOMOTOR-STIMULANT SENSITIZATION - A UNITARY PHENOMENON
Autore:
WISE RA; LEEB K;
Indirizzi:
CONCORDIA UNIV,DEPT PSYCHOL,1455 DEMAISONNEUVE BLVD W MONTREAL H3G 1M8 QUEBEC CANADA CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL MONTREAL H3G 1M8 QUEBEC CANADA
Titolo Testata:
Behavioural pharmacology
fascicolo: 4, volume: 4, anno: 1993,
pagine: 339 - 349
SICI:
0955-8810(1993)4:4<339:PS-AUP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; NEONATAL 6-OHDA-LESIONED RATS; INDUCED ROTATIONAL BEHAVIOR; INDUCED LOCOMOTOR-ACTIVITY; A10 DOPAMINE REGION; FREELY MOVING RATS; SUBSTANTIA NIGRA; NUCLEUS-ACCUMBENS; D-AMPHETAMINE; PARS RETICULATA;
Keywords:
CONDITIONING; PSYCHOMOTOR; SENSITIZATION; STIMULANT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
130
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Wise e K. Leeb, "PSYCHOMOTOR-STIMULANT SENSITIZATION - A UNITARY PHENOMENON", Behavioural pharmacology, 4(4), 1993, pp. 339-349

Abstract

Repeated intermittent treatment with psychomotor stimulants or opiates sensitizes animals to the locomotor-activating effects of these drugs. Whereas such sensitization may have important implications for the understanding of addiction, mental illness, and the cellular basis of memory, its mechanisms remain only partially understood. Psychomotor-stimulant sensitization can result in relatively permanent changes in the response of the mesolimbic dopamine system to these agents and to avariety of stressors, but the process does not depend upon simple activation of dopaminergic neurons. Psychomotor sensitization can be produced by direct (apomorphine, bromocriptine) and indirect (amphetamine,cocaine) dopamine agonists that inhibit the firing of dopaminergic neurons and thus reduce impulse-dependent dopamine release. Moreover, some treatments that cause dopaminergic activation and dopamine (DA)-dependent locomotion fail to cause robust psychomotor sensitization. While nucleus accumbens injections of amphetamine cause DA release and enhanced locomotion, they do not sensitize the animals to subsequent systemic amphetamine. On the other hand, ventral tegmental injections of amphetamine inhibit the DA system and DA-dependent locomotion but none the less sensitize the animal to subsequent systemic amphetamine treatment. While some drugs (cocaine, amphetamine, morphine, heroin) cross-sensitize animals to each other, other drugs (bromocriptine, quinpirole) sensitize animals to themselves and each other but not to cocaine or heroin. While some cases of sensitization involve Pavlovian association of environmental cues with the drug state, others seem largely independent of such conditioning. Thus it appears that there is more thanone phenomenon and more than one mechanism of psychomotor sensitization.

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Documento generato il 25/01/20 alle ore 06:20:30