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Titolo:
MURINE CLUSTERIN - MOLECULAR-CLONING AND MESSENGER-RNA LOCALIZATION OF A GENE ASSOCIATED WITH EPITHELIAL DIFFERENTIATION PROCESSES DURING EMBRYOGENESIS
Autore:
FRENCH LE; CHONN A; DUCREST D; BAUMANN B; BELIN D; WOHLWEND A; KISS JZ; SAPPINO AP; TSCHOPP J; SCHIFFERLI JA;
Indirizzi:
UNIV GENEVA,SCH MED,DIV NEPHROL CH-1211 GENEVA 4 SWITZERLAND UNIV GENEVA,SCH MED,DIV ONCOHEMATOL CH-1211 GENEVA 4 SWITZERLAND UNIV GENEVA,SCH MED,DEPT PATHOL CH-1211 GENEVA 4 SWITZERLAND UNIV GENEVA,SCH MED,INST HISTOL & EMBRYOL CH-1211 GENEVA 4 SWITZERLAND UNIV LAUSANNE,INST BIOCHEM CH-1066 EPALINGES SWITZERLAND
Titolo Testata:
The Journal of cell biology
fascicolo: 5, volume: 122, anno: 1993,
pagine: 1119 - 1130
SICI:
0021-9525(1993)122:5<1119:MC-MAM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE ATTACK COMPLEX; GROWTH-FACTOR-BETA; RETE TESTIS FLUID; SULFATED GLYCOPROTEIN-2; CELL-DEATH; OLFACTORY MUCOSA; DEVELOPING MOUSE; LUNG DEVELOPMENT; SERTOLI CELLS; HUMAN PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
L.E. French et al., "MURINE CLUSTERIN - MOLECULAR-CLONING AND MESSENGER-RNA LOCALIZATION OF A GENE ASSOCIATED WITH EPITHELIAL DIFFERENTIATION PROCESSES DURING EMBRYOGENESIS", The Journal of cell biology, 122(5), 1993, pp. 1119-1130

Abstract

Clusterin is a broadly distributed glycoprotein constitutively expressed by various tissues and cell types, that has been shown to be involved in cell-cell adhesion and expressed during cellular differentiation in vitro. To assess the suggested participation of clusterin in these processes in vivo, we have cloned the cDNA encoding murine clusterinand studied the cellular distribution of clusterin mRNA during murineembryogenesis. Sequence analysis of the cDNA encoding murine clusterin revealed 92 and 75% sequence identity with the rat and human cDNAs, respectively, and conservation of the predicted structural features which include alpha-helical regions and heparin-binding domains. From 12.5 d of development onwards, the clusterin gene is widely expressed indeveloping epithelia, and selectively localized within the differentiating cell layers of tissues such as the developing skin, tooth, and duodenum where proliferating and differentiating compartments are readily distinguished. In addition, transient and localized clusterin gene expression was detected in certain morphogenetically active epithelia. In the lung, abundant gene transcripts were detected in cuboidal epithelial cells of the terminal lung buds during branching morphogenesis,and in the kidney, clusterin gene expression in the epithelial cells of comma and S-shaped bodies coincided with the process of polarization. Our results demonstrate the in vivo expression of the clusterin gene by differentiating epithelial cells during murine embryogenesis, andprovide novel evidence suggesting that clusterin may be involved in the differentiation and morphogenesis of certain epithelia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:09:52