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Titolo:
INTERLEUKIN-7 IS PRODUCED BY MURINE AND HUMAN KERATINOCYTES
Autore:
HEUFLER C; TOPAR G; GRASSEGER A; STANZL U; KOCH F; ROMANI N; NAMEN AE; SCHULER G;
Indirizzi:
INNSBRUCK UNIV,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA IMMUNEX CORP SEATTLE WA 98101
Titolo Testata:
The Journal of experimental medicine
fascicolo: 3, volume: 178, anno: 1993,
pagine: 1109 - 1114
SICI:
0022-1007(1993)178:3<1109:IIPBMA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL GROWTH-FACTOR; LANGERHANS CELLS; T-CELLS; GENE-EXPRESSION; PROLIFERATION; RECEPTOR; LINEAGE; IL-7; LEUKEMIA; CULTURE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Heufler et al., "INTERLEUKIN-7 IS PRODUCED BY MURINE AND HUMAN KERATINOCYTES", The Journal of experimental medicine, 178(3), 1993, pp. 1109-1114

Abstract

Interleukin 7 (IL-7) was originally identified as a growth factor forB cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well. Constitutive IL-7 mRNA expression so far had been demonstrated inbone marrow stromal cell lines, thymus, spleen, and among nonlymphoidtissues in liver and kidney. Here we show that both murine and human keratinocytes express IL-7 mRNA and release IL-7 protein in biologically relevant amounts. The physiological or pathological relevance of keratinocyte-derived IL-7 is presently unknown. Our finding that keratinocytes can produce IL-7 in concert with reports that IL-7 is a growth factor for in vivo primed antigen-specific T cells, as well as for T lymphoma cells suggests, however, that keratinocyte-derived IL-7 is important in the pathogenesis of inflammatory skin diseases and cutaneousT cell lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:56:51