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Titolo:
REDUCTION OF BONE-DENSITY - AN EFFECT OF GONADOTROPIN-RELEASING-HORMONE ANALOG TREATMENT IN CENTRAL PRECOCIOUS PUBERTY
Autore:
SAGGESE G; BERTELLONI S; BARONCELLI GI; BATTINI R; FRANCHI G;
Indirizzi:
UNIV PISA,DEPT PAEDIAT,CHAIR PREVENT PAEDIAT,ENDOCRINE UNIT,VIA ROMA 67 I-56125 PISA ITALY
Titolo Testata:
European journal of pediatrics
fascicolo: 9, volume: 152, anno: 1993,
pagine: 717 - 720
SICI:
0340-6199(1993)152:9<717:ROB-AE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE; GNRH ANALOG; CHILDREN; AGONIST; WOMEN; ENDOMETRIOSIS; MINERALIZATION; PARAMETERS; SECRETION; DANAZOL;
Keywords:
CENTRAL PRECOCIOUS PUBERTY; GONADOTROPIN-RELEASING HORMONE ANALOG; BONE MINERALIZATION; BONE MINERAL DENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Saggese et al., "REDUCTION OF BONE-DENSITY - AN EFFECT OF GONADOTROPIN-RELEASING-HORMONE ANALOG TREATMENT IN CENTRAL PRECOCIOUS PUBERTY", European journal of pediatrics, 152(9), 1993, pp. 717-720

Abstract

Gonadal steroids drive the significant bone mineral increase that occurs at puberty. Oestrogen deprivation in women results in bone loss. We investigated bone mineralization by single photon absorptiometry in girls with central precocious puberty (n = 13, age 3.8-8.5 years) before and during 1 year of treatment with gonadotropin releasing hormone analogue (GnRH-a = long-acting D-Trp6-GnRH, 60 mug i.m. every 28 days). Before GnRH-a therapy, bone mineral density (BMD) was significantly higher in patients than in ten control girls matched for chronologicalage (patients 0. 575 +/- 0.097 g/cm2, controls 0.433 +/- 0.049 g/cm2,p < 0.001). Patient BMD was not significantly different from that of ten control girls matched according to patient bone age (0. 550 +/- 0.046 g/CM2, P = NS). During GnRH-a treatment, pituitary-gonadal axis was suppressed and patient BMD significantly decreased (6 months: -6.0%,P < 0.002 vs baseline; 12 months: -8.0%, P < 0.001 vs baseline). We conclude that in girls with precocious puberty the activation of gonadal steroid secretion induces an increase in bone mineralization and that oestrogen deprivation by GnRH-a treatment caused a significant decrease in BMD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 04:35:04