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Titolo:
METOCLOPRAMIDE IN THE TREATMENT OF REFLUX ESOPHAGITIS - A COMPARISON OF NORMAL AND CONTROLLED-RELEASE FORMULATIONS
Autore:
MCLOUGHLIN J; MILLER AJ;
Indirizzi:
NAPP LABS LTD,DEPT MED,CAMBRIDGE SCI PK,MILTON RD CAMBRIDGE CB4 4GW ENGLAND NAPP LABS LTD,DEPT MED,CAMBRIDGE SCI PK,MILTON RD CAMBRIDGE CB4 4GW ENGLAND MATER HOSP BELFAST NORTH IRELAND
Titolo Testata:
Current medical research and opinion
fascicolo: 3, volume: 13, anno: 1993,
pagine: 145 - 153
SICI:
0300-7995(1993)13:3<145:MITTOR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOPHAGITIS;
Keywords:
METOCLOPRAMIDE; DELAYED-ACTION PREPARATIONS; ESOPHAGITIS, PEPTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
J. Mcloughlin e A.J. Miller, "METOCLOPRAMIDE IN THE TREATMENT OF REFLUX ESOPHAGITIS - A COMPARISON OF NORMAL AND CONTROLLED-RELEASE FORMULATIONS", Current medical research and opinion, 13(3), 1993, pp. 145-153

Abstract

Twenty patients with reflux oesophagitis were recruited into a randomized, single (investigator)-blind, two-part crossover study of controlled-release metoclopramide ('Gastrobid Continus' tablets) 15 mg given twice daily, and normal-release metoclopramide ('Maxolon'), 10 mg given 4-times daily. Both treatment regimens were efficacious in reducing the severity of heartburn, the incidence of waking at night due to pain from heartburn and the severity of gastro-intestinal symptoms. The incidence of volunteered and sought side-effects/symptoms was similar on both treatments. More patients preferred the controlled-release thanthe normal-release formulation. It is concluded that 15 mg controlled-release metoclopramide twice daily and 10 mg normal-release metoclopramide 4-times daily are equally effective and well-tolerated treatmentregimens, but that the controlled-release formulation has the advantage of a smaller dose and twice daily administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 09:40:20