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Titolo:
INFLUENCE OF AMINOPHYLLINE AND 8-(P-SULFOPHENYL)THEOPHYLLINE ON THE ANTICONVULSIVE ACTION OF DIPHENYLHYDANTOIN, PHENOBARBITAL, AND VALPROATE AGAINST MAXIMAL ELECTROSHOCK-INDUCED CONVULSIONS IN MICE
Autore:
BOROWICZ K; KOZICKA M; KLEINROK Z; CZUCZWAR SJ;
Indirizzi:
LUBLIN MED SCH,DEPT PHARMACOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND LUBLIN MED SCH,DEPT PHARMACOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND
Titolo Testata:
Journal of neural transmission
fascicolo: 2, volume: 93, anno: 1993,
pagine: 157 - 163
SICI:
0300-9564(1993)93:2<157:IOAA8O>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON ANTIEPILEPTIC DRUGS; PROTECTIVE ACTION; INDUCED SEIZURES; ADENOSINE; DIAZEPAM; CAFFEINE; ELECTROCONVULSIONS; CARBAMAZEPINE; TRANSMISSION; POTENTIATION;
Keywords:
ANTIEPILEPTIC DRUGS; AMINOPHYLLINE; 8-(P-SULFOPHENYL)THEOPHYLLINE; SEIZURES;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Borowicz et al., "INFLUENCE OF AMINOPHYLLINE AND 8-(P-SULFOPHENYL)THEOPHYLLINE ON THE ANTICONVULSIVE ACTION OF DIPHENYLHYDANTOIN, PHENOBARBITAL, AND VALPROATE AGAINST MAXIMAL ELECTROSHOCK-INDUCED CONVULSIONS IN MICE", Journal of neural transmission, 93(2), 1993, pp. 157-163

Abstract

Aminophylline (theophylline2 . ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophyllineat 50 mg/kg (0.238 mmol of anhydrous theophylline/kg). In contrast, 8-(p-sulfophenyl)theophylline (a theophylline derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) didnot influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:59:42