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Titolo:
ADRENAL-CORTICAL AND MEDULLARY RESPONSES TO ACETYLCHOLINE AND VASOACTIVE-INTESTINAL-PEPTIDE IN CONSCIOUS CALVES
Autore:
EDWARDS AV; JONES CT;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND UNIV OXFORD,INST MOLEC MED,CELLULAR & DEV PHYSIOL LAB OXFORD OX3 9DS ENGLAND
Titolo Testata:
Journal of physiology
, volume: 468, anno: 1993,
pagine: 515 - 527
SICI:
0022-3751(1993)468:<515:AAMRTA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FASCICULATA-RETICULARIS CELLS; SPLANCHNIC NERVE-STIMULATION; CHROMAFFIN CELLS; CATECHOLAMINE SECRETION; SYNTHETIC ADRENOCORTICOTROPIN; MUSCARINIC RECEPTORS; MESSENGER-RNA; POLYPEPTIDE; CORTEX; GLAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Edwards e C.T. Jones, "ADRENAL-CORTICAL AND MEDULLARY RESPONSES TO ACETYLCHOLINE AND VASOACTIVE-INTESTINAL-PEPTIDE IN CONSCIOUS CALVES", Journal of physiology, 468, 1993, pp. 515-527

Abstract

1. Adrenal responses to intra-aortic infusions of acetylcholine and vasoactive intestinal peptide (VIP) have been investigated in functionally hypophysectomized calves given exogenous adrenocorticotrophic hormone (ACTH, 2 ng min-1 kg-1 i. v.). 2. Infusions of VIP at a dose of 0.13 mug min-1 kg-1 caused a small, but significant increase in adrenaline and noradrenaline output which was, however, far below the level recorded previously in response to acetylcholine (0.7 mug min-1 kg-1). In contrast, these doses of the two agonists produced closely similar rises in adrenal cortisol output. 3. The steroidogenic effects of acetylcholine and VIP were found to be strictly additive and no evidence ofpotentiation was obtained in relation to either cortical or medullaryresponses or in the case of any of the cardiovascular responses whichwere monitored. 4. Intra-aortic infusions of VIP, at a dose which produced a substantial increase in adrenal steroidogenesis (0.065 mug min-1 kg-1), had no effect on the output of catecholamines, enkephalin-like immunoreactivity or corticotrophin-releasing factor, either in the presence or absence of acetylcholine. 5. It is concluded that VIP is unlikely to modulate adrenal medullary responses to muscarinic stimulation in this species as it has been claimed to do in the rat and does not potentiate adrenal steroidogenesis in response to acetylcholine as it does to ACTH.

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Documento generato il 29/09/20 alle ore 12:38:25