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Titolo:
LIPID VESICLES LOADED WITH THYMOPENTIN - CHARACTERIZATION AND IN-VITRO ACTIVITY ON TUMORAL CELLS
Autore:
PANICO AM; PIGNATELLO R; MAZZONE S; CARDILE V; BINDONI M; CORDOPATRI F; VILLARI A; MICALI N; MAZZONE G;
Indirizzi:
IST CHIM FARMACEUT & TOSSICOL,CATTEDRA TECN & LEGISLAZ FARMACEUT,CITTA UNIV,VIALE A DORIA 6 I-95125 CATANIA ITALY IST CHIM FARMACEUT & TOSSICOL,CATTEDRA TECN & LEGISLAZ FARMACEUT,CITTA UNIV,VIALE A DORIA 6 I-95125 CATANIA ITALY UNIV CATANIA,FAC FARM,CATTEDRA TECN & LEGISLAZ FARMACEUT I-95124 CATANIA ITALY UNIV CATANIA,IST FISIOL I-95124 CATANIA ITALY UNIV CATANIA,FAC MED & CHIRURG,IST PATOL GEN I-95124 CATANIA ITALY UNIV MESSINA,DIPARTIMENTO FARM CHIM I-98100 MESSINA ITALY CNR MESSINA,IST TECN SPETTROSCOPICHE MESSINA ITALY
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1-3, volume: 98, anno: 1993,
pagine: 19 - 28
SICI:
0378-5173(1993)98:1-3<19:LVLWT->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOSOMES; THYMOPOIETIN; PENTAPEPTIDE; ENCAPSULATION; HORMONE; LINE; TP-5;
Keywords:
MULTILAMELLAR LIPOSOME; THYMOPENTIN; LIPOSOME-CELL INTERACTION; LYMPHOCYTE; IM9 LYMPHOBLASTOID CELL; K562 ERYTHROLEUKEMIC CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Panico et al., "LIPID VESICLES LOADED WITH THYMOPENTIN - CHARACTERIZATION AND IN-VITRO ACTIVITY ON TUMORAL CELLS", International journal of pharmaceutics, 98(1-3), 1993, pp. 19-28

Abstract

The cytotoxic activity on tumoral cells of thymopentin (TP5), a synthetic pentapeptide corresponding to residues 32-36 of thymopoietin, wasevaluated after inclusion in multilamellar liposomes. These were madeby all neutral (zwitterionic) phospholipids as well as those containing positively (stearylamine, SA) OT negatively charged (DPPS) lipids. Vesicles were also prepared containing cholesterol, and were characterized by tight scattering dimensional analysis and differential scanning calorimetry. The effect of charged species and of the presence of cholesterol on TP5 incorporation was studied. For the different kinds ofliposomes, loaded with sodium fluoresceinate, the rate of interactionafter incubation with lymphocytes in a normal or tumoral (IM9 lymphoblastoid cells) state was also evaluated. TP5-loaded vesicles were assayed on two tines of tumoral cells (IM9 and K562) to assess the abilityof liposomal carriers to potentiate the cell growth inhibitory activity of the drug. SA-containing positive liposomes appeared as the most efficacious, resulting in 87% inhibition on IM9 cells, with an amount of liposomes containing 100 ng of TP5.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 08:48:42