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Titolo:
ENDOGENOUS SOMATOSTATIN POSSIBLY CONTROLS PANCREATIC GROWTH - FURTHEREVIDENCE FOR FEEDBACK-REGULATION
Autore:
RUNZI M; MULLER MK; GOEBELL H;
Indirizzi:
BETH ISRAEL HOSP,DEPT SURG,330 BROOKLINE AVE BOSTON MA 02215 UNIV HEIDELBERG,KLINIKUM MANNHEIM,MED 4 CLIN W-6800 MANNHEIM 1 GERMANY UNIV ESSEN GESAMTHSCH,DEPT MED W-4300 ESSEN 1 GERMANY
Titolo Testata:
Regulatory peptides
fascicolo: 1, volume: 47, anno: 1993,
pagine: 65 - 72
SICI:
0167-0115(1993)47:1<65:ESPCPG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEASE INHIBITOR CAMOSTATE; CCK-ANTAGONIST L-364,718; RAT EXOCRINE PANCREAS; TRYPSIN-INHIBITOR; ENZYME SECRETION; CHOLECYSTOKININ RELEASE; CONSCIOUS RATS; CERULEIN; MECHANISM; BINDING;
Keywords:
PANCREAS; GROWTH; HYPERTROPHY; PROTEINASE INHIBITOR; SOMATOSTATIN; FEEDBACK REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Runzi et al., "ENDOGENOUS SOMATOSTATIN POSSIBLY CONTROLS PANCREATIC GROWTH - FURTHEREVIDENCE FOR FEEDBACK-REGULATION", Regulatory peptides, 47(1), 1993, pp. 65-72

Abstract

Specific inhibitors acting upon pancreatic proteinases in the gut cancause pancreatic hypertrophy ('growth'), which is probably mediated through a feedback mechanism utilizing cholecystokinin. We have proposed the involvement of somatostatin, and here test the hypothesis that endogenous somatostatin secreted into pancreatic juice may regulate pancreatic growth. Groups of rats were given the proteinase inhibitor camostate intragastrically for either 3, 7, 14, 28, or 56 days, when theywere sacrificed. In some groups the pancreata were weighed and homogenized while in other groups isolated perfused pancreatic organ preparations were performed. Somatostatin was measured in the homogenates, pancreatic juice and portal vein effluents. In camostate-fed animals, pancreatic weights increased to a maximum at 28 days, while pancreatic somatostatin content increased significantly from the third day onwards, and somatostatin secretion into pancreatic juice increased progressively until day 28. In contrast, somatostatin secretion into portal blood remained unchanged from those of untreated controls over the duration of the experiment, and its concentration was lower than in pancreatic juice. These observations provide further evidence that endogenous pancreatic somatostatin may control pancreatic growth in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:33:42