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Titolo:
DISPOSITION OF ENANTIOMERS OF SULPIRIDE IN HUMANS AND RATS
Autore:
KAMIZONO A; INOTSUME N; FUKUSHIMA S; NAKANO M; OKAMOTO Y;
Indirizzi:
KUMAMOTO UNIV HOSP,DEPT PHARMACEUT SERV,1-1-1 HONJO KUMAMOTO 860 JAPAN KUMAMOTO UNIV HOSP,DEPT PHARMACEUT SERV,1-1-1 HONJO KUMAMOTO 860 JAPAN NAGOYA UNIV,FAC ENGN,CHIKUSA KU NAGOYA 46401 JAPAN
Titolo Testata:
Biopharmaceutics & drug disposition
fascicolo: 6, volume: 14, anno: 1993,
pagine: 475 - 481
SICI:
0142-2782(1993)14:6<475:DOEOSI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED BENZAMIDE; ACID; PHARMACOKINETICS; INVERSION; ISOMERS; DRUGS;
Keywords:
SULPIRIDE; ENANTIOMER; STEREOSELECTIVE DISPOSITION; HUMAN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A. Kamizono et al., "DISPOSITION OF ENANTIOMERS OF SULPIRIDE IN HUMANS AND RATS", Biopharmaceutics & drug disposition, 14(6), 1993, pp. 475-481

Abstract

Pharmacokinetics of sulpiride enantiomers after intravenous administration of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rats. Pharmacokinetic profiles were similar in (+)- and (-)-enantiomers after intravenous administration of (+/-)-sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:28:10