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Titolo:
RELEASE OF CHEMICAL MEDIATORS AND INFLAMMATORY CELL INFLUX DURING EARLY ALLERGIC REACTION IN THE NOSE - EFFECT OF FUROSEMIDE
Autore:
PRAT J; MULLOL J; RAMIS I; ROSELLOCATAFAU J; XAUBET A; NERIN I; GELPI E; PICADO C;
Indirizzi:
UNIV BARCELONA,FAC MED,HOSP CLIN,SERV PNEUMOL,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,FAC MED,HOSP CLIN,SERV PNEUMOL,VILLARROEL 170 E-08036 BARCELONA SPAIN CSIC,DEPT NEUROQUIM,BRANCA ECOSANOIDS BARCELONA SPAIN
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 2, volume: 92, anno: 1993,
pagine: 248 - 254
SICI:
0091-6749(1993)92:2<248:ROCMAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BRONCHOCONSTRICTION; INHALED FUROSEMIDE; NASAL SECRETIONS; ASTHMATIC SUBJECTS; ANTIGEN CHALLENGE; ARACHIDONIC-ACID; METABOLITES; FRUSEMIDE; AIRWAYS; LOOP;
Keywords:
FUROSEMIDE; DERMATOPHAGOIDES PTERONYSSINUS; NASAL MUCOSA; PERENNIAL RHINITIS; PGD2; PGE2; PEPTIDE LEUKOTRIENES; 15-HETE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J. Prat et al., "RELEASE OF CHEMICAL MEDIATORS AND INFLAMMATORY CELL INFLUX DURING EARLY ALLERGIC REACTION IN THE NOSE - EFFECT OF FUROSEMIDE", Journal of allergy and clinical immunology, 92(2), 1993, pp. 248-254

Abstract

Background: We evaluated the effect of furosemide on allergen-inducedrhinitis in a double-blind, crossover, placebo controlled experiment Methods: Fourteen patients with rhinitis who were allergic to house dust were nebulized with an intranasal dose of 20 mg of furosemide or placebo before allergen challenge with an extract of Dermatophagoides pteronyssinus (100 BU). Clinical evaluation and nasal lavages with normal saline solution were performed at baseline; after placebo-furosemidenebulization, and at 10, 30, and 60 minutes after allergen challenge. Number of sneezes and a composite symptom score were recorded to evaluate clinical response. Prostaglandin E2 (PGE2), PGD2, peptide leukotrienes and 15-hydroxy 5,8,11,13-eicosatetraenoic acid (15-HETE) were measured by radioimmunoassay in nasal lavages. Cells were counted and classified as epithelial cells, neutrophils, eosinopilds, and others. Results: No differences in either clinical symptoms or cell influx afterallergen challenge were found between furosemide and placebo groups. PGE2 levels did not change after provocation, and furosemide had no effect on its production. Ten minutes after antigen challenge there was a marked increase of PGD2 (P < 0.01), peptide leukotrienes (p < 0.01),and 15-HETE (not significant) on both study days. However, no significant differences in the release of eicosanoids were found between furosemide and placebo groups. Conclusions: Our observations in the nasal mucosa suggest that furosemide has no effect on the release of proinflammatory and bronchoconstrictor metabolites (PGD2 peptide leukotrienes, and 15-HETE). In contrast to bronchial asthma, allergen-induced rhinitis was not effectively prevented by furosemide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:22:37