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Titolo:
IMMUNOMODULATORY EFFECTS OF RECOMBINANT INTERLEUKIN-3 TREATMENT ON HUMAN ALVEOLAR MACROPHAGES AND MONOCYTES
Autore:
THOMASSEN MJ; ANTAL JM; CONNORS MJ; MCLAIN D; SANDSTROM K; MEEKER DP; BUDD GT; LEVITT D; BUKOWSKI RM;
Indirizzi:
CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,9500 EUCLID AVE CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT HEMATOL CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT ONCOL CLEVELAND OH 44195 SANDOZ PHARMACEUT CORP E HANOVER NJ 00000
Titolo Testata:
Journal of immunotherapy with emphasis on tumor immunology
fascicolo: 1, volume: 14, anno: 1993,
pagine: 43 - 50
SICI:
1067-5582(1993)14:1<43:IEORIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMINE; MONONUCLEAR PHAGOCYTES; ACTIVATION; CANCER; EXPRESSION; LIPOSOMES; INDUCTION; NEOPTERIN; MELANOMA;
Keywords:
INTERLEUKIN-3; ALVEOLAR MACROPHAGES; MONOCYTES; CYTOKINES; CYTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Thomassen et al., "IMMUNOMODULATORY EFFECTS OF RECOMBINANT INTERLEUKIN-3 TREATMENT ON HUMAN ALVEOLAR MACROPHAGES AND MONOCYTES", Journal of immunotherapy with emphasis on tumor immunology, 14(1), 1993, pp. 43-50

Abstract

The purpose of these studies was to examine the effects of in vivo and in vitro recombinant IL-3 treatment on alveolar macrophage and monocyte activities associated with antitumor and antimicrobial properties. Alveolar macrophages and blood monocytes from 6 patients receiving IL-3 (125-500 mug/M2 /day) subcutaneously were isolated before therapy and at various times during the 15 days of therapy. Results indicated that tumor necrosis factor-alpha (TNF), interleukin-1beta (IL-1), and interleukin-6 (IL-6) secretion were enhanced from monocytes of all patients and from alveolar macrophages of patients receiving 500 mug/m2/day IL-3. Constitutive cytokine gene expression was present before therapy, but further enhancement was not detectable during therapy, suggesting a rapid time course of cytokine gene transcription and translation. Serum neopterin levels were elevated 2-5-fold in all patients compatible with the presence of augmented monocyte/macrophage activity. Peaklevels of neopterin did not coincide with peak levels of cytokine secretion. In vitro studies of IL-3-treated normal alveolar macrophage and monocyte populations demonstrated that IL-3 significantly augmented TNF and IL-6 secretion in monocytes, but not in alveolar macrophages. These differences in alveolar macrophage cytokine secretion observed after in vivo and in vitro IL-3 treatment may reflect the involvement of other cell populations in IL-3 modulation of alveolar macrophages invivo. Monocytes, in contrast were comparably activated by IL-3 whether presented in vitro or in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:23:41