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Titolo:
VASOPRESSIN, RENIN, AND CORTISOL RESPONSES TO HEMORRHAGE DURING ACUTEBLOCKADE OF CARDIAC NERVES IN CONSCIOUS DOGS
Autore:
ODONNELL CP; KEIL LC; THRASHER TN;
Indirizzi:
UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL,BOX 0444 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL,BOX 0444 SAN FRANCISCO CA 94143 NASA,AMES RES CTR MOFFETT FIELD CA 94035
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 265, anno: 1993,
parte:, 2
pagine: 180000220 - 180000229
SICI:
0002-9513(1993)265:1<180000220:VRACRT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE VASOPRESSIN; PLASMA VASOPRESSIN; ARTERIAL BARORECEPTORS; RELEASE; RECEPTORS; HYPOTENSION; INHIBITION; MECHANISM; SECRETION; PRESSURE;
Keywords:
BLOOD PRESSURE; BARORECEPTORS; CARDIAC RECEPTORS; ANTIDIURETIC HORMONE; ADRENOCORTICOTROPIC HORMONE; ANGIOTENSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Odonnell et al., "VASOPRESSIN, RENIN, AND CORTISOL RESPONSES TO HEMORRHAGE DURING ACUTEBLOCKADE OF CARDIAC NERVES IN CONSCIOUS DOGS", The American journal of physiology, 265(1), 1993, pp. 180000220-180000229

Abstract

The effect of acute cardiac nerve blockade (CNB) on the increases in plasma renin activity (PRA), arginine vasopressin (AVP), and cortisol in response to a 30 ml/kg hemorrhage was determined in conscious dogs (n = 9). Procaine was infused into the pericardial space to produce acute reversible CNB, or saline was infused in the control hemorrhage. Blood was removed from the inferior vena cava at a rate of 1 ml.kg-1.min-1. In the control hemorrhage, plasma AVP increased from 1.8 +/- 0.3 to 219 +/- 66 pg/ml, PRA increased from 0.63 +/- 0.20 to 3.08 +/- 0.91ng angiotensin I (ANG I).ml-1.3 h-1, and cortisol increased from 1.4 /- 0.2 to 4.0 +/- 0.7 mug/dl. When the hemorrhage was repeated duringacute CNB, plasma AVP increased from 2.8 +/- 1.6 to 185 +/- 59 pg/ml,PRA increased from 0.44 +/- 0.14 to 2.24 +/- 0.27 ng ANG I.ml-1.3 h-1, and cortisol increased from 1.9 +/- 0.3 to 5.4 +/- 0.6 mug/dl, and none of the increases differed significantly from the responses during the control hemorrhage. Left atrial pressure fell significantly after removal of 6 ml/kg of blood, but mean arterial pressure was maintainedat control levels until blood loss reached 20 ml/kg during pericardial infusion of either saline or procaine. The declines in MAP at the 30ml/kg level of hemorrhage in both treatments were similar. These results demonstrate that acutely blocking input from cardiac receptors does not reduce the increases in plasma AVP, cortisol, and PRA in response to a 30 ml/kg hemorrhage. The results of this study do not support the hypothesis that input from cardiac receptors is required for a normal AVP response to hemorrhage and suggest that other receptors, presumably arterial baroreceptors, can stimulate AVP and cortisol secretion in the absence of signals from the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:44:22