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Titolo:
INHIBITION OF CHEMORECEPTOR INPUTS TO NUCLEUS OF TRACTUS-SOLITARIUS NEURONS DURING BARORECEPTOR STIMULATION
Autore:
MIFFLIN SW;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,7703 FLOYD CURL DR SAN ANTONIOTX 78284
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 265, anno: 1993,
parte:, 2
pagine: 180000014 - 180000020
SICI:
0002-9513(1993)265:1<180000014:IOCITN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID BARORECEPTORS; BODY; RESPONSES; REFLEX; SINUS; CAT;
Keywords:
ARTERIAL CHEMOREFLEX; ARTERIAL BAROREFLEX; CENTRAL CARDIOVASCULAR REGULATION; CENTRAL RESPIRATORY REGULATION; CENTRAL NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Mifflin, "INHIBITION OF CHEMORECEPTOR INPUTS TO NUCLEUS OF TRACTUS-SOLITARIUS NEURONS DURING BARORECEPTOR STIMULATION", The American journal of physiology, 265(1), 1993, pp. 180000014-180000020

Abstract

The reflex effects of arterial chemoreceptor activation are attenuated as arterial pressure is elevated and augmented as arterial pressure is decreased. This study was designed to test the hypothesis that excitatory arterial chemoreceptor inputs to neurons in the nucleus tractussolitarius (NTS) are inhibited by arterial baroreceptors. In pentobarbital sodium-anesthetized, mechanically ventilated, paralyzed cats, extracellular recordings were obtained from NTS neurons, which were excited after brief activation of ipsilateral carotid body chemoreceptors. During increases in arterial pressure, carotid sinus nerve (CSN)-evoked discharge was 45-112% of the control-evoked discharge at the prevailing level of arterial pressure (n = 70). Inhibition of CSN-evoked discharge during increased arterial pressure was significant when evoked discharge was <90% of control (n = 31; 67 +/- 2%, mean percent of control-evoked discharge +/- SE; P < 0.01, Wilcoxon signed-rank test). Theinhibition of CSN-evoked discharge was reduced after section of both vagi, both aortic nerves, and the contralateral CSN (n = 5, P < 0.05). These results demonstrate that activation of arterial baroreceptors attenuates excitatory chemoreceptor inputs to a subpopulation of NTS neurons. The inhibition appears to be mediated by disfacilitation. The results indicate that baroreceptor modulation of arterial chemoreflexesoccurs at an early stage of the reflex arc, within the NTS. The results also suggest that sympathoinhibition evoked by baroreceptors might include, as a component, reduced sympathoexcitatory, i.e., chemoreceptor, drive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:19:20